The paradigm in vertebrates is that, once sex determination occurs and testes or ovaries are formed, secondary sexual differentiation (male vs. female characteristics) is dependent on male or female hormones that are produced. Recently, D. Zhao and colleagues studied three chickens that were bilateral gynandromorphs, with the right side of the body being clearly female and the left side of the body clearly male [Nature 464: 237 (2010)]. Propose experimental questions that can be investigated using these chickens to test this paradigm. What alternative interpretation contrasts with the paradigm?
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