Solutions For An Introduction to Genetic Analysis Chapter 11 Problem 3P

Promoter mutations cluster at positions -10 and -35 positions. This is because these are the DNA sequences that are recognized and bound by the sigma subunit of the polymerase.

Alterations to these sequences will affect the ability of the RNA polymerase holoenzyme to recognize the promoter.

DNA sequences, for efficient transcription.

The boxed sequences are highly conserved sequences. Mutations in these genes effect the transcription. The mutations can be a single nucleotide or paired of nucleotides or deletion may occur.