(Research Problem) Conformational transitions in proteins
How do proteins accomplish conformational changes? How is it that proteins convert precisely and efficiently from one conformation to another? Recall from Figure 6.34 that any folding/unfolding transition must involve movement across a free-energy landscape, and try to imagine the nature of a conformational transition. Are bonds formed and broken along the way? What kinds of bonds and interactions might be involved? Suggest how such conformational transitions might occur. One reference that will be useful in this regard is:
Boehr, D., 2009. During transitions proteins make fleeting bonds.Cell 139:1049-1051
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