(Research Problem) The nature and roles of linear motifs in proteinsIn addition to domains...

(Research Problem) The nature and roles of linear motifs in proteins

In addition to domains and modules, there are other significant sequence patterns in proteins – known aslinear motifs – that are associated with a particular function. Consult the biochemical literature to answer the following questions:

 What are linear motifs?

 How are they different than domains?

 What are their functions?

 How can they be characterized?

There are several papers that are good starting points for this problem:

Neduva, V. and Russell, R., 2005. Linear motifs: evolutionary interactions switches.FEBS Letters 579:3342-3345.

Gibson, T., 2009. Cell regulation: determined to signal discrete cooperation.Trends in Biochemical Sciences 34:471-482.

Diella, F., Haslam, N., Chica., C. et al., 2009. Understanding eukaryotic linear motifs and their role in cell signaling and regulation.Frontiers of Bioscience 13:6580-6603.