When a native protein in solution is heated to a high enough temperature, its polypeptide chain will unfold to become the denatured protein. The temperature at which a large portion of the protein unfolds is called the melting temperature. The melting temperature of a certain protein is found to be 46°C, and the enthalpy of denaturation is 382 kJ/mol. Estimate the entropy of denaturation, assuming that the denaturation is a two- state process; that is, native protein→denatured protein. The single polypeptide protein chain has 122 amino acids. Calculate the entropy of denaturation per amino acid. Comment on your result.
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