Problem

Below are shown two views of the backbone representation of the Myc-Max complex binding to...

Below are shown two views of the backbone representation of the Myc-Max complex binding to DNA (PDB ID: 1NPK). Myc and Max are members of the basic helix-loop-helix (bHLH) class of DNA-binding proteins (see Chapter 29). Myc (red) and Max (blue) associate via a coiled-coil interaction and bind DNA as a dimer.

(a) Are the helices bound to the DNA likely to be amphiphihe? Explain.


(b) Where do you predict the N- and C-termini are located for Max?

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Solutions For Problems in Chapter 6