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Solutions For An Introduction to Medicinal Chemistry Chapter 4 Problem 4Q

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Solution 1

The outer layer of the cell is termed as a cell membrane. The cell membrane carries out various important functions in the cell such as cell transport, and cell signaling. Cell signaling and transport are mainly assisted by a set of proteins termed as cell membrane or transmembrane protein.

Proteins are macromolecules that play an important role in the cell. The cell synthesizes proteins using amino acid. About 20 amino acids are found in human and are involved in protein synthesis.

The primary structure contains the amino acid linked together to form chains of amino acid called peptide chain. The amino acid linked to each other by bond termed as a peptide bond.

Secondary structure has a peptide chain that gets folded into secondary structure using hydrogen bonds. These structures are of two types, alpha helix and beta-pleated sheets. The name is given as per the conformation of secondary structure form.

The tertiary structure is formed when the secondary structure gets further folded to form compact structure. It involves hydrogen bonding and van der Waals forces. Tertiary structures come together to form a macromolecule consists of same or different tertiary structure termed as quaternary structure.

The cell membrane is involved in various functions of the cell. It is a compact structure. Thus, bulky proteins would not be feasible to carry out various functions. The proteins with alpha-helix structure are found to be more complex as compared beta-pleated sheets.

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