Problem

Note that some of these problems refer to information presented in the Tools of Biochemist...

Note that some of these problems refer to information presented in the Tools of Biochemistry 5A-D.

A mutant form of polypeptide hormone angiotensin II has the amino acid composition

The following observations are made:

Trypsin yields a dipeptide containing Asp and Arg, and a hexa-peptide with all the rest.

• Cyanogen bromide cleavage yields a dipeptide containing Phe and Pro, and a hexapeptide containing all the others.
• Chymotrypsin cleaves the hormone into two tetrapeptides, of composition
• The dipeptide of composition (Pro, Phe) cannot be cleaved by either chymotrypsin or carboxypeptidase.