Use the tools of the Protein Data Bank to explore ribosome structure
The Protein Data Bank (PDB) is also a repository for nucleic acid structures. Go to the PDB at www.rcsb.org and enter the PDB ID = 1YI2. 1Y12 is the PDB ID for the structure of theH. marismortui 50S ribosomal subunit with erythromycin bound. Erythromycin is an antibiotic that acts by inhibiting bacterial protein synthesis. In the list of the display options under the image of the 50S subunit, click on one of the viewing options to view the structure. Using the tools of the viewer, zoom in and locate erythromycin within this structure. If the 50S ribosomal subunit can be compared to a mitten, where in the mitten is erythromycin?
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