Stability of compounds in new drugs. Refer to the ACS Medicinal Chemistry Letters (V...

Stability of compounds in new drugs. Refer to the ACS Medicinal Chemistry Letters (Vol. 1, 2010) study of the metabolic stability of drugs, Exercise 2.35 (p. 49). Recall that two important values computed from the testing phase are the fraction of compound unbound to plasma (fup) and the fraction of compound unbound to microsomes (fumic). A key formula for assessing stability assumes that the fup/fumic ratio is 1. Pharmacologists at Pfizer Global Research and Development tested 416 drugs and reported the fup/fumic ratio for each. These data are saved in the FUP file, and summary statistics are provided in the accompanying MINITAB printout. Suppose the pharmacologists want to determine if the true mean ratio, μ, differs from 1.

Reference: Exercise 2.35

Stability of compounds in new drugs. Testing the metabolic stability of compounds used in drugs is the cornerstone of new drug discovery. Two important values computed from the testing phase are the fraction of compound unbound to plasma (fup) and the fraction of compound unbound to microsomes (fumic). A key formula for assessing stability assumes that the fup/fumic