The structure of montelukast, an antiasthma drug, is shown here.
(a) Use Table 1.8 to identify the most acidic and most basic sites in the molecule. (Although you won’t find an exact match in structure, make a prediction based on analogy with similar groups in simpler molecules.)
(b) Write the structure of the product formed by treating montelukast with one equivalent of sodium hydroxide.
(c) Write the structure of the product formed by treating montelukast with one equivalent of HCl.
TABLE 1.8 Acidity Constants (pKa) of Acids
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