In humans, the COL1A1 locus codes for a certain collagen protein found in bone. The normal allele at this locus is denoted with S. A recessive allele s is associated with reduced bone mineral density and increased risk of fractures in both Ss and ss women. A study of 1,778 women showed that 1,194 were SS, 526 were Ss, and 58 were ss (Uitterlinden et al. 1998). Are these two alleles in Hardy–Weinberg equilibrium in this population? How do you know? What information would you need to determine whether the alleles will be in Hardy–Weinberg equilibrium in the next generation?
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