Problem

Artemisinin and mefloquine are widely used antimalarial drugs.a.   Locate the stereogenic...

Artemisinin and mefloquine are widely used antimalarial drugs.

a.   Locate the stereogenic centers in both drugs.


b.   Label each stereogenic center in mefloquine as R or S.


c.   What is the maximum number of stereoisomers possible for artemisinin?


d.   How are the N atoms in mefloquine hybridized?


e.  Can two molecules of artemisinin intermolecularly hydrogen bond to each other?


f.   What product is formed when mefloquine is treated with HCI?

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