Question

Two experimental groups of the same genetic strain of mice are being used for toxicological experiments. Each group of mice is administered the same single oral dose of a xenobiotic and monitored for acute lethality. After 4 days, all of the mice in one group are dead and all of the mice in the other group are alive. Provide six explanations for the difference in susceptibility of these two groups of mice. (2 marks each, 12 marks total) 4. a) b) c) d) e)

Answer 1

a)Whe a poor or deficient xenobiotic metablmetabolism occurs it can affect the life of the mice

b)Afer xenobiotic administration the toxic level has to be decreased but if it increases it can endanger the life and this is called as inactivation

c)When the organism has a disruption in hepatic enzymes the xenobiotic cannot be excreted leading to death of the host

d)Nutritional status of the group also can be considered

e) Environmental exposures plays a vital role in the toxicology exoexperimental study

f)Chemical disruption after the administration of xenobiotic can be a reason