Question

он о Br Me 2 4. (-)-Hamigeran B (structure shown at right) is a marine natural product isolated from the sponge Hamigera tarangaensis. It exhibits near-complete inhibition of both the herpes and polio viruses, albeit with some significant toxicity problems in vivo The following pathway shows a multistep synthesis that was used to access a precursor to hamigeran B Provide the missing intermediates, reagents, or major organic product in each box provided. You do not need to show any curved-arrow mechanisms. Note: We have not learned some of the reactions that were involved in this synthesis. You are not responsible for knowing these reactions, and you do not need to look anything up outside of what we have covered in class to correctly answer this question. (-)-Hamigeran B (two steps) но он Hcat TSCI, pyr Me 1. M MgCI OTHP 2. H* workup OM OH H,O* Cro pyridine Precursor to (-)-Hamigeran B Duplication of this problem set for any pumase other than official Harvard Extencion School be

Answer 1

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