Question

Explain how the transmission of CJD can be familial, sporadic, iatrogenic, and infectious and yet they all involve the same Prion protein.

Answer 1

• CJD is a rare ,degenerative brain disorder.
• it is a human prion disease.
• the symptoms include behavioral changes, lack of coordination, mental deterioration, blindness, weakness of extremities, and coma may occur.
• prion is a type of protein that trigger the normal protein in the brain to become abnormal.
• in acquired form of CJD the abnormal prion protein enter into the body through contaminated meat.
• in hereditary CJD , the infectious prions are developed through the mutation of normal prion in the brain.
• In the sporadic form, the infectious prions are results from an error of the cell machinery that makes proteins.
• CJD may be spread from person to person through contaminated medical equipments.