Question

TABLE 12-4 Standard Free Energy Change for Phosphate Hydrolysis Compound AGⓇ' (kJ. mol-') Phosphoenolpyruvate -61.9 1,3-Bisphosphoglycerate -49.4 ATP → AMP + PP, -45.6 Phosphocreatine -43.1 ATP ADP + P -30.5 Glucose-1-phosphate -20.9 PP, 2P, -19.2 Glucose-6-phosphate -13.8 Glycerol-3-phosphate -9.2 thioester bond AGⓇ' = -31.5 kJ•mol-1 H20 O CH3 -C-s-CoA I CH3 -C-0- + COA-SH Acetyl-CoA The formation of acetyl CoA from acetate is an ATP driven reaction: Acetate + ATP + COA <--> acetyl COA + AMP + PPI 1. a. Calculate Delta Gº for this reaction. Use data in table. b.The PPi formed in the preceding reaction is rapidly hydrolyzed in vivo because of the ubiquity of inorganic pyrophosphatase. The DGº for the hydrolysis of PPi is 19.2 kJ mol-1. Calculate the DGº' for the overall reaction, including pyrophosphate hydrolysis. c. What effect does the hydrolysis of PPI have on the formation of acetyl COA?

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Answer 1

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