Homework 7 - Due 10/29/19 at the beginning of class (4 pts) 1) Rank the following...
Provide the MAJOR product(s) for the following reactions. SN2 and E2 reaction will only give one major product (the substitution of elimination product) major product (the substitution or elimin SOCI, Pyridine HCI (excess) Heat Oh ot H2SO4, H20 Nas DMF, 25 °C NaOH H20, 55 °C Br
1) Provide the starting material for the following reaction. (0.5 pts) Он Он 1) Hg(OAc)2, H20 2) NaBH (provide starting material) 2) Provide the major organic product(s) for the following reactions. If stereoisomers are formed, please show both stereoisomers. (0.5 pts each) 1) BH3 THF a) 2)120 NaOH 1) NaOH, H-O, 55°C b) 2) OsO4 t-BuOOH 1-BuOH, NaOH Br2 c) CCl4 H2O, H2SO d) H9SO4 2 equivalents HBr e) 3) The following ction generates an ether. Provide the major organic...
H20.55°C 3) Provide the major elimination product and a mechanism for the following reaction. Please include all intermediates and use arrows to show the movement of electrons (you do not need to show transition states. (1 pt) но y no hayo
1. A) Show each possible product for the reaction below and predict the major product. Be sure. to include all geometric isomers. (1 pt) b Na B) Draw the rotamer that leads to the major product for the reaction above as a Newman projection. (1 pt) 2. Circle the substrates which can undergo elimination through the E2 mechanism. (Hint: substrates may not be drawn in the proper conformation for an E2 reaction). (0.5 pts) to x Kto 3. Circle the...
With explanation please -- thanks! 7. (8 pts) Predict the major and the minor alkene product of the following E2 reaction and show stereochemistry where appropriate OTS tBu 7 NaOCH3, DMF, heat H₂CT major minor
VI. Reactions (21 pts) Provide the major product in the following reaction. It as the product Show your work for each stepll Pay attentio Stereochemistry! Product in the following reaction. If no reaction occurs, write" NR stepll pay attention to Regiochemistry and TSCI ElyN 1. CHy-Br (xs) 2 A0,0,H,O, A H-CI E-G NaBH,CN a. NaNs, EtOH b. H20, он 1. SOCI, pyridine 2. NaN, DMF 3. LIAIH, EL 0
VI. Reactions (21 pts) Provide the major product in the following reaction. If no reaction occurs, write "NR as the product. Show your work for each step!! Pay attention to Regiochemistry and Stereochemistry! TSCI EtyN 1. CHg-Br (xs) 2. Ag20, H20, A H-CI Et20 Sold lo no? NaBH CN a. NaNg, EtOH b. H20,4 OH 1. SOCI, pyridine 2. NaN, DMF 3. LIAIH, Et20
5. Mechanism: (20 pts) Show the detailed reaction mechanism including all relevant arrows, intermediates, inorganic products, relevant resonance structures, and stereochemistry for the following reaction. heat OH H-Br step 1 step 2 step 3 step 4 Product(s) a. This is a S2/Sx1/E/E2/ reduction / oxidation mechanism. b. What is the product if the starting alcohol is reacted with PBrz? Product(s) with PBrz c. Reaction with PBr3 is a S2/S1/Ej / E2 / reduction / oxidation mechanism.
4. Predict the products of the following reactions & indicate whether they are most likely to go through an SN2, SN1, E1, or E2 mechanism. NaCN DMSO NaOH CH3OH heat Only one product is formed in the following E2 elimination reaction. Draw an arrow-pushing mechanism for the reaction and provide the correct product structure. Include a 3-D drawing (chair conformation) displaying proper stereochemistry of the transition state to explain formation of only the major product. CH3 •Br NaOCH3 ~"'CHS
What major product forms from the following E2 elimination reaction? Answer options: Question 4 1.5 pts What major product forms from the following E2 elimination reaction? CH3 Br excess KOH ethanol, heat CH3 Hints: (1) Please be sure you understand where the possible anti-periplanar eliminations can occur for this substituted cyclohexane. Therefore, it is recommended that you convert the starting alkyl halide into its chair structural representation. (2) The ring beta-proton should be trans to the alpha-halogen leaving group in...