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Non-systemic : M1 receptor antagonists Pirenzepine (Gastrozepin) a. Antimuscarinic (lowers gastric motility, delays gastric e

Hey please help with the description of these drugs. This is a project on gastrointestinal pharmacology. Will rate

1. Which one would you prescribe? Which one works best for treating ulcers?

2. What is their potentiation effects if combined with other drugs such as cimetidine and ranitidine? Combining with anticholinergics to delay gastric emptying?

3. Key distinguishing features about these drugs

4. Anything else worth mentioning

thank you so much

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Answer #1

1.pirenzepine are best for other 2 drugs for treating duodanal ulcer

Beacuse pirenzepine effects on other organ are less so side effect are less with pirenzepine

Side effect like dry mouth , constipation are more with other 2 drug

2. Cimetidine like drug reduse acid secretion in stomach so very beneficial with anticholinergics

It's combination are best in duodanal ulcer

3. Mepenzolate are inhibit contractions in colon so it side effect are constipation

So it use are very less

Propenthalin are more potent to pirenzepine for anticholinergics action on git but propenthalin have more side effect

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