Question

• Describe the morphology of erythrocytes, the mechanism, and primary cause of the following anemias: Pernicious anemia, folate deficiency anemia, iron deficiency anemia, thalassemia, and sickle cell anemia.

Answer 1

Anemia	morphology of eryterythrocyte	primary cause	Mechanism
Pernicious anemia	Macrocytic and less in number.	Deficiency of vitamin B12	Lessen the red blood cells and results inability to absorb vitamins B12 in intestine
Folate deficiency anemia	megaloblastic	Folic acid deficiency	Lessen RBC cause reduced oxygen carrying capacity
Iron deficiency anemia	microcytic	Deficiency of iron in diet Blood loss	Body losses to produce healthy RBCs
Thalassemia	less in number	Mutations in DNA of haemoglobin	mutation causes abnormalities in alpha and beta chain of haemoglobin results abnormal production of RBC.
Sickle cell anemia	Rigid, sticky and sickle shaped	Mutation in gene	Polymerization of deoxy Hbs results replacement of glutamine a I'd causes abnormal rbc