Homework Answers
A, maintenance dose is a rate of drug administration equal to the rate of elimination of steady state..Half lives of the drug will be steady state level..
Maintenance dose rate=
desired peak concentration (ug/l)X clearance (L/hr)
45 X 2= 90ug/ml
B, Therapeutic drug monitoring (TDM) defined as the drug dosage by maintaining plasma or blood drug concentration with in targeted therapeutic range .plasma concentration obtained during early treatment stages..
45X 20= 900ug/ml
C, ED 95 is the median dose required to achieve a 95% reduction in maximum response of the dose..ED 95 is the ED 50 from the cumulative log dose response curve when the quantum is 95% reduction in twitch height..
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Problem 4 Now you would like to attain an effective dose concentration and maintain that concentration....
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
plz, answer all questions clearly and correctly. i am begging you ex of activity? in a...
plz, answer all questions clearly and correctly. i am begging
you
ex of activity? in a single intra exactly, what 3. A new drug was given in a single intravenous dose of 200 mg to an 80-kg adult male patient. After 6 hours, the plasma drug concentration of drug was 1.5 mg/100 mL of plasma. Assum- ing that the apparent V, is 10% of body weight, compute the total amount of drug in the body fluids after 6 hours. What...
ID: A 22. The most widely used opioid, sulfate, is an effective drug for moderately severe...
ID: A 22. The most widely used opioid, sulfate, is an effective drug for moderately severe pain 23. All opioid analgesics are derived from or a synthetic substance like it. is an illegal narcotic substance in the United States and is not used in medicine. 25. A physician orders 30 mg of codeine orally four times a day for a patient. The available tablets are 60 mg. How many tablets will the nurse instruct the patient to take with each...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8 AND…in addition to answering each question, state 2 other questions aft...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
1. A patient with a methicillin resistant Staphylococcus aureus infection Cipro 400 mg in 200 ml...
1. A patient with a methicillin resistant Staphylococcus aureus infection Cipro 400 mg in 200 ml DSW ordered. The pharmacy recommends that the Cipro be infused at a rate of 200 mg/h. What should be the pump rate? – 2. Mrs. England has sepsis and has an order for Kefzol i Gm in 50 mL of DSW IVPB over 15 minutes. Available tubing has 60 gtts/mL. What should be the infusion rate? 3. A patient with rapid atrial fibrillation has...
1. Amoxicillin 1.5gm po is to be given over 24 hours in divided doses TID. IF...
1. Amoxicillin 1.5gm po is to be given over 24 hours in divided doses TID. IF 250 mg capsules are supplied, how many capsules are to be given per dose? Answer 2. Nortriptyline HCL oral solution is supplied in bottles labeled 5 ml is equivalent to 10 mg. How many ml should be administered if 45 mg is prescribed? Answer 3. If the prescribed dosage of cephalexin hydrochloride is 4 gm over 24 hrs. in four divided doses, how many...
I would like to compare my answers. im not sure if I did them right: questions...
I would like to compare my answers. im not sure if I did them
right: questions 41.- 46.
(brand) 37. Pituluny dependen CHAPTER 9 Drugs Used in Hormonal, Endocrine, and Reproductive Disorders 193 1 A 1200-lb Holstein cow will be treated for an ovarian cyst with 100 mcg of Cystorelin. Cystorelin contains 50 mcg/mL. How much of the product will you draw up? 45. A 20-1b poodle with pituitary-dependent hyperadrenocorticism will be treated with trilostane (Vetoryl) at a dosage of...
4. 15 marks) Let C denote the concentration of paracetamol in your blood. When you take the parac...
4. 15 marks) Let C denote the concentration of paracetamol in your blood. When you take the parac- etamol C goes up quickly and then declines slowly over the next few hours, as your liver clears the drug from your body (or as the drug gets metabolised or excreted) Here are some typical data.1 The "test drug" and "reference drug" refer to two slightly different forms of paracetamol; the data show how the test version of the drug is absorbed...
would like both problems done or at most #3 ! 2. Suppose you take a $300,000...
would like both problems done or at most #3 !
2. Suppose you take a $300,000 thirty year fixed-rate mortgage at 5.75% two discount points, monthly payments. At the end of the second year you inherit $20,000 from your now-favorite aunt. You decide to apply this $20,000 to the principal balance of your loan A. (1 pt) How many monthly payments are remaining after the extra lump sum payment is made? B. (1 pt) What is your net interest savings...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
plz, answer all questions clearly and correctly. i am begging
you
ex of activity? in a single intra exactly, what 3. A new drug was given in a single intravenous dose of 200 mg to an 80-kg adult male patient. After 6 hours, the plasma drug concentration of drug was 1.5 mg/100 mL of plasma. Assum- ing that the apparent V, is 10% of body weight, compute the total amount of drug in the body fluids after 6 hours. What...
ID: A 22. The most widely used opioid, sulfate, is an effective drug for moderately severe pain 23. All opioid analgesics are derived from or a synthetic substance like it. is an illegal narcotic substance in the United States and is not used in medicine. 25. A physician orders 30 mg of codeine orally four times a day for a patient. The available tablets are 60 mg. How many tablets will the nurse instruct the patient to take with each...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
1. A patient with a methicillin resistant Staphylococcus aureus infection Cipro 400 mg in 200 ml DSW ordered. The pharmacy recommends that the Cipro be infused at a rate of 200 mg/h. What should be the pump rate? – 2. Mrs. England has sepsis and has an order for Kefzol i Gm in 50 mL of DSW IVPB over 15 minutes. Available tubing has 60 gtts/mL. What should be the infusion rate? 3. A patient with rapid atrial fibrillation has...
1. Amoxicillin 1.5gm po is to be given over 24 hours in divided doses TID. IF 250 mg capsules are supplied, how many capsules are to be given per dose? Answer 2. Nortriptyline HCL oral solution is supplied in bottles labeled 5 ml is equivalent to 10 mg. How many ml should be administered if 45 mg is prescribed? Answer 3. If the prescribed dosage of cephalexin hydrochloride is 4 gm over 24 hrs. in four divided doses, how many...
I would like to compare my answers. im not sure if I did them
right: questions 41.- 46.
(brand) 37. Pituluny dependen CHAPTER 9 Drugs Used in Hormonal, Endocrine, and Reproductive Disorders 193 1 A 1200-lb Holstein cow will be treated for an ovarian cyst with 100 mcg of Cystorelin. Cystorelin contains 50 mcg/mL. How much of the product will you draw up? 45. A 20-1b poodle with pituitary-dependent hyperadrenocorticism will be treated with trilostane (Vetoryl) at a dosage of...
4. 15 marks) Let C denote the concentration of paracetamol in your blood. When you take the parac- etamol C goes up quickly and then declines slowly over the next few hours, as your liver clears the drug from your body (or as the drug gets metabolised or excreted) Here are some typical data.1 The "test drug" and "reference drug" refer to two slightly different forms of paracetamol; the data show how the test version of the drug is absorbed...
would like both problems done or at most #3 !
2. Suppose you take a $300,000 thirty year fixed-rate mortgage at 5.75% two discount points, monthly payments. At the end of the second year you inherit $20,000 from your now-favorite aunt. You decide to apply this $20,000 to the principal balance of your loan A. (1 pt) How many monthly payments are remaining after the extra lump sum payment is made? B. (1 pt) What is your net interest savings...
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