How does acetaminophen cause toxicity in overdose (what is the pathogenesis behind the toxicity)?
conjugation
conjugation
glucuronide<------ Acetaminophen-----> sulfate
moiety
|
| P450 (2E1)
|
|
N-acetyl-p-benzo-quinone imine
(Toxic)
|
| (glutathione)
|
|
|
Cysteine and mercapturic acid
Conjugates (nontoxic)
How does acetaminophen cause toxicity in overdose (what is the pathogenesis behind the toxicity)?
what are the complications of acetaminophen overdose?
What are the stages of clinical presentation of acetaminophen overdose?
A patient presents with acetaminophen toxicity with a plasma concentration of 200 ug/mL. Knowing that acetaminophen has a Vd of around 50 L, what dose did this person take?
why does taking more than the regular dosage of acetaminophen cause bleeding of the stomach? i cant find anything tell me how it actually causes it
what is the cause, species involved, pathogenesis, gross and microscopic findings of the following conditions; 1.exudative epidermitis 2.Dermatophilosis 3.Demodicosis 4. sarcoptic mange.
Ms. T is a 17-year-old woman who took an acetaminophen overdose after her boyfriend broke up with her. She states that she did not want to kill herself but just wanted to scare her boyfriend. Ms. T is having difficulty facing the need for a psychiatric evaluation and the potential for severe liver damage. Clinical Assessment Ms. T was admitted to the critical care unit from the emergency department in stable condition. She is awake; alert; and oriented to person,...
An explosion brings down an old building, leaving behind a pile of rubble. Does this cause a thermodynamic entropy increase? If so, where? Write a paragraph explaining your reasoning.
14. What is the pathogenesis of EBV? (i.e. How does it affect B cells?) 15. What are the signs, symptoms and lab findings of mononucleosis? 16. What are common signs and symptoms of Hodgkin Lymphoma? 17.How might you distinguish between non-Hodg kin lymphoma and Hodgkin lymphoma? 18. What is a Philadelphia chromosome? 19. What would be seen in the bone marrow biopsy of an acute leukemia?
How does quorum sensing promote pathogenesis? Why might this physiology have evolved? What are the different regulatory circuits associated with quorum sensing and how do they compare/contrast for AIP vs. AHL autoinducers? In the various presented quorum sensing systems, which proteins are involved in synthesizing and sensing the autoinducer. What kind of autoinducers (autoinducer peptide vs. AHLs) are associated with specific quorum sensing systems?
Consider caffeine and acetaminophen: What structural features (functional groups) cause one to move farther than the other on the TLC plate?