A patient presents with acetaminophen toxicity with a plasma concentration of 200 ug/mL. Knowing that acetaminophen...
A patient presents with acetaminophen toxicity with a plasma concentration of 200 ug/mL. Knowing that acetaminophen has a Vd of around 50 L, what dose did this person take?
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A patient presents with acetaminophen toxicity with a plasma
concentration of 200 ug/mL. Knowing that acetaminophen...
Question A patient was presented with suspected salicylic acid (SA) overdose. The initial plasma concentration of...
Question A patient was presented with suspected salicylic acid (SA) overdose. The initial plasma concentration of SA was 2000 mg/L and 1 hour later it is 1000 mg/L. a) What is the half-life of SA in this patient? (2) b) Calculate the elimination constant of SA in this patient. (4) c) Calculate how many hours will be needed for the SA to reach a level of 62.5 mg/L if the kel = 0.693 in this patient. (answer 5 hours) (4)...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
1. A new drug was given in a single intravenous dose of 200 mg to an...
1. A new drug was given in a single intravenous dose of 200 mg to an 80- kg adult male patient. The apparent VD is 0.8 L/kg, and the drug is eliminated by 1st order kinetics. Compute the initial drug plasma concentration. 2. A drug has an elimination half-life of 4 hours and follows first-order kinetics. If a single 600-mg dose is given to a patient by IV bolus, what percent of the dose is lost in 12 hours?
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8 AND…in addition to answering each question, state 2 other questions aft...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
A drug that fully saturates the intestinal transporters required for its absorption necessitates 2.5 hours to be complet...
A drug that fully saturates the intestinal transporters required for its absorption necessitates 2.5 hours to be completely absorbed after administering a 100mg dose orally to a volunteer. Once absorbed, the drug has rapid distribution in the body. A 50 mg dose of the drug administered by IV bolus to the same volunteer (in a separate research session) results in plasma concentrations of 1800 ug/L at time 0 hr and 1150 ug/L at time 3.0 hr. If a patient with...
(12) A 45 year old male patient presents with the following lab values. What do you...
(12) A 45 year old male patient presents with the following lab values. What do you conclude about his iron status? (2 points) HgB: 14.1 g/dL ok Serum Ferritin: 240 ug/LO RBC folate: 463 nmol/Lm/ Serum B12: 263 pmol/L Serum C-reactive protein: 26 mg/L a) His iron status is adequate, since ferritin concentrations are above the cutoff for deficiency b) You cannot interpret his plasma ferritin concentration because he has inflammation le may have iron overload, since ferritin concentrations are...
1. A patient with a methicillin resistant Staphylococcus aureus infection Cipro 400 mg in 200 ml...
1. A patient with a methicillin resistant Staphylococcus aureus infection Cipro 400 mg in 200 ml DSW ordered. The pharmacy recommends that the Cipro be infused at a rate of 200 mg/h. What should be the pump rate? – 2. Mrs. England has sepsis and has an order for Kefzol i Gm in 50 mL of DSW IVPB over 15 minutes. Available tubing has 60 gtts/mL. What should be the infusion rate? 3. A patient with rapid atrial fibrillation has...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
5-6. A 74-year-old retired mechanic is admitted with a myocardial infarction and a severe acute cardiac...
5-6. A 74-year-old retired mechanic is admitted with a myocardial infarction and a severe acute cardiac arrhythmia. You decide to give lidocaine to correct the arrhythmia. 5. A continuous intravenous infusion of lidocaine, 1.92 mg/min, is started at 8 AM. The average pharmacokinetic parameters of lidocaine are: Vd 77 L; clearance 640 mL/min; half-life 1.4 h. What is the expected steady-state plasma concentration? (A) 40 mg/L (B) 3.0 mg/L (C) 0.025 mg/L (D) 7.2 mg/L (E) 3.46 mg/L 6. Your...
1. Your patient weighing 44 lbs has an order for Tylenol (acetaminophen) 325 mg stat. The...
1. Your patient weighing 44 lbs has an order for Tylenol (acetaminophen) 325 mg stat. The recommendations for acetaminophen is 10 - 15 mg/kg/dose. Tylenol solution is available is 160mg per teaspoon. A. Is this ordered dose safe? B. How many mls would you give 2. A child has an order for ibuprofen 185 mg orally prn q6h. Ibuprofen solution is available as 100 mg tsp. How many ml do you need for this dose? 3. A client weighing 110...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
(12) A 45 year old male patient presents with the following lab values. What do you conclude about his iron status? (2 points) HgB: 14.1 g/dL ok Serum Ferritin: 240 ug/LO RBC folate: 463 nmol/Lm/ Serum B12: 263 pmol/L Serum C-reactive protein: 26 mg/L a) His iron status is adequate, since ferritin concentrations are above the cutoff for deficiency b) You cannot interpret his plasma ferritin concentration because he has inflammation le may have iron overload, since ferritin concentrations are...
1. A patient with a methicillin resistant Staphylococcus aureus infection Cipro 400 mg in 200 ml DSW ordered. The pharmacy recommends that the Cipro be infused at a rate of 200 mg/h. What should be the pump rate? – 2. Mrs. England has sepsis and has an order for Kefzol i Gm in 50 mL of DSW IVPB over 15 minutes. Available tubing has 60 gtts/mL. What should be the infusion rate? 3. A patient with rapid atrial fibrillation has...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
1. Your patient weighing 44 lbs has an order for Tylenol (acetaminophen) 325 mg stat. The recommendations for acetaminophen is 10 - 15 mg/kg/dose. Tylenol solution is available is 160mg per teaspoon. A. Is this ordered dose safe? B. How many mls would you give 2. A child has an order for ibuprofen 185 mg orally prn q6h. Ibuprofen solution is available as 100 mg tsp. How many ml do you need for this dose? 3. A client weighing 110...
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