Question

SCAN Homework the last weck She also complained of being increasingly short of breath, and she is noticeably wheeng on A 14-year-old girl with cystic fibrosis has complained of sn increased cough productive of green spoim al S physical examination. Arterial blood was drawn and sampled, revealing the following values 7.30 How would the kidneys try to compevate for the girTs acid-hane imhalance? pH 50 mm Hg рCO: pO2 Hemoglobin- O2 saturation 55 mm Hg 45 % [нсо3] 24 meq/ liter Answer the following Questions: What causes cystic fibrasis? Describe the nathonhysiologic mechanisms of the disease This girl has also had a long history of diarrhea and poor weight gain. Explain why 5 2 How would you classify this girl's acid-base status? List some other causes ot this type of acid-base disturbance 6 3 How does cystic fibrosis cause this acid-base imbalance?

Answer 1

1, Cystic fibrosis occurs due to a deficiency of cystic fibrosis transmembrane conductance regulator(CFTR) gene. It controls the movement of salt and water in our body cells. sudden changes in the CFTR gene make mucous become thicker when it buildup there will be the abnormal thickness in various organs.
2, Less than 7.4pH indicate acidosis
Paco2 more than 42mmHg indicate a respiratory component of ABG results.
HCO3 within the normal range.
when pH level less and paco2 level high indicate respiratory acidosis and hypoxemia due to less o2 saturation.
3, When there is a high CFTR gene that limits the flow of water and salt in the body cells. this thick and sticky mucus clogs the tubes of the airway in and out of the lungs and causes symptoms like wheezing, persistent cough, breathing difficulty, lung infection and thick mucus. it makes changes in their acid-base balance.
4, Kidney compensation for respiratory acidosis by tubular cells reabsorbing more Hco3 from fluids and secreting more H+ and more Hco3 leads to ammonia genesis cause the high formation of NH3 buffer. In chronic conditions compensated respiratory acidosis will be slow and provide time for a kidney to compensate.