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pathophysiology of alcoholic cirrhosis and signs and symptoms

pathophysiology of alcoholic cirrhosis and signs and symptoms

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Pathophysiology

Alcohol reaches the stomach and it is absorbed in the small intestine but it is mostly metabolized in the liver .The enzymes like systolic ADH ,MEOS ,CYP2E1 are the chief to metabolize the liver.This leads to oxygen reaction causing oxidative stress and decrease in oxygen supply, meanwhile the liver starts accumulating the fats.If not treated this will slowly lead to the death off the cells called cirrhosis of liver .The endotoxin will be released in the gut and exhibiting signs and symptoms

Signs and symptoms

  • The increased level of bilirubin will cause yellowing of sclera , skin and urine
  • As endotoxin are released in the HUT it causes nausea, vomiting, abdominal pain, decreased food intake
  • Inflamed liver causes right upper quadrant pain
  • Increased fatigue
  • Bruises
  • Weight loss
  • Edema
  • Ascites
  • Elevated body temperature
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