Homework Answers
The overall reaction of citric acid cycle is as follows
Acetyl-CoA + 3 NAD+ + Q + FAD + GDP + Pi + 2 H2O → CoA-SH + 3 NADH + 3 H+ + QH2 + FADH+ + GTP + 2 CO2
where Q is ubiquinone and Pi is inorganic phosphate
The acetyl-CoA, has been oxidized to two molecules of carbon dioxide.
Three molecules of NAD were reduced to NADH.
One molecule of FAD was reduced to FADH2.
One molecule of GTP (the equivalent of ATP) was produced.
NADH and FADH2 molecules act as electron carriers and are used to generate ATP in the next stage of glucose metabolism, oxidative phosphorylation.
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5. Overall Summary equation of Citric Acid Cycle? Please include number of CoA, NAD, FAD, GDP...
acetyl-CoA COA The reactions of the citric acid cycle are shown in the image. As labeled...
acetyl-CoA COA The reactions of the citric acid cycle are shown in the image. As labeled in the diagram, reactions 1, 3, and 4 are regulation points in the citric acid cycle. oxaloacetate citrate synthase citrate NADH +Hi 7 malate dehydrogenase NAD malate aconitase 2 Which molecule inhibits reaction 1? isocitrate 7 fumarase NAD isocitrate dehydrogenase 3 NADH + H+ O citrate O NAD acetyl-CoA + CO2 fumarate C-ketoglutarate FADH succinate O dehydrogenase FAD O-ketoglutarate a dehydrogenase NAD + COA...
Oxaloacetic Acetyl Coa » Coa Citric acid acid NADH NAD Malic acid Isocitric acid Fumaric acid...
Oxaloacetic Acetyl Coa » Coa Citric acid acid NADH NAD Malic acid Isocitric acid Fumaric acid NAD CO2 NADH FADH, FAD+ Q-ketoglutaric acid Succinic acid CO2 NAD+ Succinyl-CoA NADH ADP+P; ATP Figure 9.1 2 26) Refer to Figure 9.1. If citric acid has six carbon atoms, how many carbon atoms does succinic acid have? A) 4 B) 12 C)5 D)1 E) 6 27) Refer to Figure 9.1. Starting with one acetyl CoA molecule, what is the maximum number of ATP...
The succinyl CoA to citrate pathway of the citric acid cycle is shown below. Identify the...
The succinyl CoA to citrate pathway of the citric acid cycle is
shown below. Identify the missing intermediates by dragging the
item to the appropriate position. Then identify the missing
cofactors below.
I have pulled up the "drop down" menu for
the options for the "Cofactors"
Citrate H2C-CO2 H2C-co Succinyl CoA H2O AcCoA HO CO2 H2 GDP+P GTP CoA-SH CoA-SH CoA CO2 HO-C-H CH2 CO2 CO2 CO2 CH2 CH2 CO2 CO2 H-C-OH CH2 CO2 2 H CO2 CH2 CO2 factor...
not sure about reaction 3 and 4 acetyl-CoA COA The reactions of the citric acid cycle...
not sure about reaction 3 and 4
acetyl-CoA COA The reactions of the citric acid cycle are shown in the figure Reactions 1, 3, and 4 are regulation points in the citric acid cycle. 1 citrate oxaloacetate 1 synthase citrate NADH + NAD malate dehydrogenase aconitase 2 malate Which of the molecules inhibits reaction 1? Isocitrate HO 17 fumarase NAD socitrate 3 dehydrogenase S D NADP ADP ОАТР O citrate synthase fumarate FADHI succinate co-ketoglutarate dehydrogenase ci-ketoglutarate NAD dehydrogenase +...
3. Draw one turn of the citric acid cycle starting from a radio-labeled (*) acetyl-CoA shown...
3. Draw one turn of the citric acid cycle starting from a radio-labeled (*) acetyl-CoA shown below. Trace the fate of radio-labeled carbons and fully label each structure of intermediates through the citric acid cycle. Include the names of enzymes involved (in the table below), number each step, and indicate the names of each consumed or produced product. (Hint: There are symmetrical molecules present) (12 marks) CoA Нас 5. 2. 6 7. 3. 4. 8
8. The citric acid cycle requires acetyl-CoA to begin. Describe how acetyl-CoA is produced for the...
8. The citric acid cycle requires acetyl-CoA to begin. Describe how acetyl-CoA is produced for the citric acid cycle.
The effect of inorganic phosphate on the activity of the citric acid cycle can be studied...
The effect of inorganic phosphate on the activity of the citric acid cycle can be studied in mitochondrial extracts by monitoring the rate of CO2 production. a. Why is the citric acid cycle dependent upon inorganic phosphate? b. Acetyl CoA is added to a rat liver mitochondrial extract containing excess NAD+, FAD, and GDP. The rate of CO2 production increases and then levels off very quickly; the addition of addition acetyl CoA has no effect. Explain why CO2 production begins...
QUESTION 25 The citric acid cycle cannot function if o2 is not available; why is this...
QUESTION 25 The citric acid cycle cannot function if o2 is not available; why is this OA. O2 is required for the redox reactions of the citric acid cycle. B. All of these answers are correct OC. The electron transport chain will not function without 02, thus the NAD+ and FAD needed for the citric acid cycle will not be regenerated. OD. None of these answers are correct O E 02 is the final electron acceptor of the citric acid...
6. Citric Acid Cycle Draw the complete Citric Acid Cycle pathway, include: (a) Total number of...
6. Citric Acid Cycle Draw the complete Citric Acid Cycle pathway, include: (a) Total number of steps in Citric Acid Cycle? (b) Specify the type of reaction in each step? (c) Name the enzymes in each step? (d) How many redox reactions are present in Citric Acid Cycle?
During times of increased glucose-6-phosphate concentration, the overall rate of the citric acid cycle will ________....
During times of increased glucose-6-phosphate concentration, the overall rate of the citric acid cycle will ________. Increase Decrease Remain unchanged During times of increased succinyl-CoA concentration, the overall rate of the citric acid cycle will ________. Increase Decrease Remain unchanged
acetyl-CoA COA The reactions of the citric acid cycle are shown in the image. As labeled in the diagram, reactions 1, 3, and 4 are regulation points in the citric acid cycle. oxaloacetate citrate synthase citrate NADH +Hi 7 malate dehydrogenase NAD malate aconitase 2 Which molecule inhibits reaction 1? isocitrate 7 fumarase NAD isocitrate dehydrogenase 3 NADH + H+ O citrate O NAD acetyl-CoA + CO2 fumarate C-ketoglutarate FADH succinate O dehydrogenase FAD O-ketoglutarate a dehydrogenase NAD + COA...
Oxaloacetic Acetyl Coa » Coa Citric acid acid NADH NAD Malic acid Isocitric acid Fumaric acid NAD CO2 NADH FADH, FAD+ Q-ketoglutaric acid Succinic acid CO2 NAD+ Succinyl-CoA NADH ADP+P; ATP Figure 9.1 2 26) Refer to Figure 9.1. If citric acid has six carbon atoms, how many carbon atoms does succinic acid have? A) 4 B) 12 C)5 D)1 E) 6 27) Refer to Figure 9.1. Starting with one acetyl CoA molecule, what is the maximum number of ATP...
The succinyl CoA to citrate pathway of the citric acid cycle is
shown below. Identify the missing intermediates by dragging the
item to the appropriate position. Then identify the missing
cofactors below.
I have pulled up the "drop down" menu for
the options for the "Cofactors"
Citrate H2C-CO2 H2C-co Succinyl CoA H2O AcCoA HO CO2 H2 GDP+P GTP CoA-SH CoA-SH CoA CO2 HO-C-H CH2 CO2 CO2 CO2 CH2 CH2 CO2 CO2 H-C-OH CH2 CO2 2 H CO2 CH2 CO2 factor...
not sure about reaction 3 and 4
acetyl-CoA COA The reactions of the citric acid cycle are shown in the figure Reactions 1, 3, and 4 are regulation points in the citric acid cycle. 1 citrate oxaloacetate 1 synthase citrate NADH + NAD malate dehydrogenase aconitase 2 malate Which of the molecules inhibits reaction 1? Isocitrate HO 17 fumarase NAD socitrate 3 dehydrogenase S D NADP ADP ОАТР O citrate synthase fumarate FADHI succinate co-ketoglutarate dehydrogenase ci-ketoglutarate NAD dehydrogenase +...
3. Draw one turn of the citric acid cycle starting from a radio-labeled (*) acetyl-CoA shown below. Trace the fate of radio-labeled carbons and fully label each structure of intermediates through the citric acid cycle. Include the names of enzymes involved (in the table below), number each step, and indicate the names of each consumed or produced product. (Hint: There are symmetrical molecules present) (12 marks) CoA Нас 5. 2. 6 7. 3. 4. 8
8. The citric acid cycle requires acetyl-CoA to begin. Describe how acetyl-CoA is produced for the citric acid cycle.
QUESTION 25 The citric acid cycle cannot function if o2 is not available; why is this OA. O2 is required for the redox reactions of the citric acid cycle. B. All of these answers are correct OC. The electron transport chain will not function without 02, thus the NAD+ and FAD needed for the citric acid cycle will not be regenerated. OD. None of these answers are correct O E 02 is the final electron acceptor of the citric acid...
6. Citric Acid Cycle Draw the complete Citric Acid Cycle pathway, include: (a) Total number of steps in Citric Acid Cycle? (b) Specify the type of reaction in each step? (c) Name the enzymes in each step? (d) How many redox reactions are present in Citric Acid Cycle?
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