Question

1. In order for a solution to generate heat when irradiated by microwaves the solvent must have?

2. Identify what the solvent is for this reaction. Draw its structure.

cetyl anthranilic acid into a large, dry, test tube place 0.68 g of anthranilic acid, 2.2 mL of acetic anhydride and a Doung chip. Upon the addition of the acetic anhydride the tube may become warm. Swirl the tubo brany to mix the reagents. Place the tube into a beaker. Place the beaker in the middle of the turntable in a microwave oven and irradiate at full power until the mixture boils for about 1 second (should take no more than 30 seconds of heating). After cooling to room temperature, add 3 mL of distilled water to the mixture. Heat the reaction mixture for 15 seconds at full power in the microwave oven. During this time the solution should boll again for about one second. Allow the reaction mixture to cool slowly on the bench top. Once crystal formation is compete collect the crystals by vacuum filtration and wash them with a minimum quantity (no more than 3 mL each) of 1.) ice cold water, and then 2.) ice cold methanol. Obtain a crude yield and crude melting point for this reaction product. Recrystallize your crude product from 90% methanol/water starting with approximately 15 mL of solvent. This one sentence means at least four steps and probably 30 minutes worth of work so make sure you reread pp. 124-125 in Padias. Methanol has a low boiling point so dissolve the crystals in a flask and try to minimize solvent evaporation. Activated charcoal should be unnecessary. Wash the collected crystals with cold methanol. Leave the product in the Hirsch funnel with the vacuum on for 2 to 3 minutes to dry it completely. Dry the crystals in the oven for about 10 minutes. Obtain a yield and melting point. Calculate a percent yield. The crystals should now glow yellow or yellow-green under the UV lamp. Place your crystals in a storage vial and take them and a stirring rod into a dark room. Watch carefully as you crush your crystals for the emission of bright blue sparks.

Answer 1

Acetic anhydride acts as a solvent for this reaction.

Troit oh + Cho -o "NH2 tel poi ab Nita anthranilic acid KINH Acetic anhydride. N-acetyl anthranilic aby microwave acid 420/4 El benzisoxazinone intermediate which is not isolated Hence, the reaction to produce N-acetyl anthranilic acid proceeds via an interemediate benzi soxazinane, which is not isolated, however converts to the product by treatment of water. Hence, in the first step, Acetic anhydride acts as solveut to carvey out the reaction.