Discussion about (GRA) Means Glucocorticoid-remediable aldosteronism Tell us also what a lab value outside of the...
Discussion about (GRA) Means Glucocorticoid-remediable aldosteronism
- Tell us also what a lab value outside of the normal limits might mean
- (what would an abnormal value for this lab possibly indicate?) Include at least 2 weblink references.
Homework Answers
Ans) Glucocorticoid remediable aldosteronism also describable as aldosterone synthase hyperactivity, is an autosomal dominant disorder in which the increase in aldosterone secretion produced by ACTH is no longer transient.
- Aldosterone suppression by dexamethasone, and high 18-hydroxycortisol and 18-oxocortisol levels are used to differentiate glucocorticoid-remediable aldosteronism (GRA) from other forms of primary aldosteronism.
- The long PCR technique is a reliable and simple test to at least exclude GRA in patients with primary aldosteronism. A short term dexamethasone suppression test of aldosterone can be misleading in identifying GRA. The prevalence of GRA in primary aldosteronism remains to be established.
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