Cholinergic agonists act on acetylcholine a major neurotransmitter in the parasympathetic nervous system.Especially direct acting cholinergic agonists acts on the muscarinic receptors i.e. M2, present on the heart and its hyperactivity can block the human heart.
Some of the examples of such cholinergic agonists are methacholine, tacrine and bethanechol.
list cholinergic responnses not normally caused when the usual therapeutic doses of muscarinic agonist are administered and explain why these effects do not occur
1. State the responses that a muscarinic agonist would be expected to cause through direct activation of muscarinic cholinergic receptors (consider bethanechol). The student should focus on the main “targets” of parasympathetic nervous system activity: eyes, respiratory system, heart and blood vessels, gastrointestinal (GI) and urinary tracts, and the secretory activity of exocrine glands (e.g., lacrimal, mucous, and so on). 2. List cholinergic responses not normally caused when the usual therapeutic doses of a muscarinic agonist are administered and explain...
What is the overall effect of ACh & direct cholinergic drugs on the heart? What is the overall effect of ACh & direct cholinergic drugs on the eye? What is the overall effect of ACh & direct cholinergic drugs on bronchial smooth muscle? What is the overall effect of ACh & direct cholinergic drugs on the urinary bladder? What is the overall effect of ACh & direct cholinergic drugs on glands? What is the overall effect of ACh & direct...
In a frog, are the cholinergic receptors controlling heart rate of the same type as those controlling stroke volumes?
What are cholinergic fibers and why are they so named?
•An anthropologist discovers the fossilized heart of an extinct animal. The evidence indicates that the organism's heart was large, well-formed, and had four chambers, with no connection between the right and left sides. What can be a reasonable conclusion supported by these observations?
Farmer Brown developed cholinergic crisis after spraying his fields with insecticide. Why wouldn't pyridostigmine be an efficient treatment? Pyridostigmine will irreversibly bind to the cholinergic receptor. Pyridostigmine will reversibly bind to the cholinergic receptor. Pyridostigmine does not have an effect on irreversible anticholinesterases. Pyridostigmine does not have an effect on reversible anticholinesterases.
Why are the effects of Acetylcholinesterase Inhibitors effectively the same as the effects of Ach and direct cholinergic agents? Why do anticholineric/cholinergic receptor blocking drugs like atropine (muscarinic antagonist) exhibit effects that are opposite those of Ach, Direct Cholinegic Drugs, and Indirect Cholinergic Drugs (i.e., acetylcholinesterase inhibitors)? Direct vs Indirect-Acting cholinergics ? Direct vs Indirect-Acting adrenergics? Know which receptor is associated with which second messenger system, and whether that messenger system is activated or inhibited by an agonist or antagonist....
Why can an enlarged heart be both a blessing and a curse?
Why does atherosclerosis lead to a heart attack or stroke? It promotes inflammation, which injures heart or brain tissue. It causes oxidized low-density lipoproteins to attack heart and brain cells, depriving them of oxygen and nutrients. It reduces or blocks blood flow to the tissues below the clogged artery, resulting in tissue death. It causes blood vessels to be so damaged, they stop delivering blood to cells in the brain and heart.