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why cholinergic agonist can stop animal heart?!

why cholinergic agonist can stop animal heart?!
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Answer #1

Cholinergic agonists act on acetylcholine a major neurotransmitter in the parasympathetic nervous system.Especially direct acting cholinergic agonists acts on the muscarinic receptors i.e. M2, present on the heart and its hyperactivity can block the human heart.

Some of the examples of such cholinergic agonists are methacholine, tacrine and bethanechol.

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