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How many regions of chromosome 6 with causative variants were identified in Schizophrenia? ​

How many regions of chromosome 6 with causative variants were identified in Schizophrenia? ​

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Ans:4 different regions.

It is known that the MHC locus on chromosome 6 is a strong risk area.

McCarroll and colleagues explored on the particular region of the MHC with the highest GWAS score.and idenified the C4 gene

The C4 gene can exist in multiple copies (from one to four) on each copy of chromosome 6, and has four different forms: C4A-short, C4B-short, C4A-long, and C4B-long. These are the regions with causative factors for schizophrenia.

Supportive studies

  • A. Sekar et al., “Schizophrenia risk from complex variation of complement component 4,” Nature,doi:10.1038/nature16549, 2016.
  • Schizophrenia Gene' Discovery Sheds Light on Possible Cause​ - Rachel Rettner
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