Question

peer review evidence base article on endocrine drugs on endocrine drug class

Answer 1

Endocrine medication is divided into three categories

1)diabetic agents

2)hormone agents

3)hormone antagonists

1)DIABETICS AGENTS ::::A)::Chlorpropamide,Tolbutamide(sulfonylureas 1 st generation)::glipizide,glyburide(sulfonylureas 2 nd generation)it inhibits ATP sensitive potassium channels resulting in beta cell depolarization and insulin release.it is mainly used for the treatment of type 2 diabetes

side effects::Hypoglycemia,renal failure,disulfiram effects

B)::Bigunides e.g.::metformin. It helps for gluconeogenesis,insulin sensitivity,glycolysis.this is used to treat type 2 diabetes and metabolic syndrome

sideeffects::::lactic acidosis

C)alpha glycosidase inhibitors e.g.acarbose,miglitol. It prevents break down of carbohydrates into single glucose

side effects::diarrhea,

D):Thioglitazones e.g.proglitazone,Rosiglitazone. This will help to increase insulin sensitivity in peripheral tissues

Side effects::heart failure,hepatitis toxicity

2)HORMONE ANTAGONIST ::A)Anti-Estrogens e.g.:Tamoxifen.it binds with estrogen receptors to inhibit the effects of estrogen .this used to treat breast cancer

side effects::increased bone density,endometrial cancer

B)anti androgens e.g.flytamide Which blocks action of testosterone .it is used to treat prostatecancer

side effects::G.I disturbances C)enzyme inhibitors:e.g.,anastrozole.it inhibits aromatase.it is used to treat fertility,breast cancer

side effects:: osteoporosis,bone fractures

3)HORMONE AGENT A)Estrogen e.g.:polyestradiol.it decreases testosterone synthesis and induce chemical castration etc.this for palliative prostate cancer

side effects::nausea,headache

B)Progestins e.g.:Megestrol acetate .it supresses leutinizing hormone by inhibitation ofpitutary function.it helps to stimulate appetite

side effects:: weight gain,vomiting

C)gonadotropin releasing hormone e.g.: leuprorelin which inhibits gonadotropin secretions.this is used to treat fertility,hormone responsive cancer

side effects:: fatigue ,ideas,sweating etc.