13. Complete the following table (10-20 words each). Drugs Indication Mechanism of action Ibuprofen (Brufen) Pain
Homework Answers
IBUPROFEN:
| Class | Non steroidal anti inflammatory drug |
| Brand names | Advil,Motrin,Ibu-tab,Brufen |
| Mechanism | It is a cyclooxygenase(COX) enzyme,which is used for the synthesis of prostagladins via the arachidonic pathway.Cyclooxygenase convert the arachidonic acid to prostagladin H2 in the human body.Ibuprofen inhibit the cyclooxygenase enzyme that lower the lower the production of prostagladins.It has anticoagulant effect by inhibiting the conversion of arachidonic acid to thromboxane A2 which is important for platelet aggregation. |
| Indication | Inflammation, Fever, Menstrual cramps, Osteoarthritis, Rheumatoid arthritis, Patent ductus arteriosus |
| Side effects | Abdominal pain,Ulceration,nausea,headache,constipation,Tinnitus,Heart failure,edema |
| Contraindication | Liver problems,Asthma,Hypertension,Peripheral arterial disease,Urticaria |
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13. Complete the following table (10-20 words each).
Drugs
Indication
Mechanism of action
Ibuprofen (Brufen)
Pain
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