Be able to explain the mechanism of action of the following anti-cancer drugs: Vinblastine, and Avastin
Be able to explain the mechanism of action of the following anti-cancer drugs: Vinblastine, and Avastin
Homework Answers
Answer. Vinblastine is a drug used as chemotherapy. It shows tow mechanism, 1. at very low concentration it will hinder or suppress microtubule dynamics, 2. At high concentration it block microtubule mass formation.
Avastin is a monoclonal humanized antibody that inhibit angiogenesis by inhibiting vascular endothelial growth factor A (VEGF-A). VEGF-A is a protein that stimulates angiogenesis
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Be able to explain the mechanism of action of the following
anti-cancer drugs: Vinblastine, and Avastin
Look up the following cancer drugs/therapyand explain how each works. In your answer include mechanism of...
Look up the following cancer drugs/therapyand explain how each works. In your answer include mechanism of action, drug/therapytarget (specific protein), and specific pathway targeted. Explain why this is an anti-cancer drug/therapy(what is it doing to the cancer cells?) Be sure to include references used .a.ABT-737 b.ONYX-015 c.vinblastine d.cyclapolin e.TNP-470
Question 1 Anti-cholinergic drugs (e.g. Cogentin) are effective in alleviating the symptoms of Parkinson's disease. Using...
Question 1 Anti-cholinergic drugs (e.g. Cogentin) are effective in alleviating the symptoms of Parkinson's disease. Using a diagram, explain the mechanism of action of these drugs. Imagine a patient with Parkinson's and schizophrenia. Why would a typical anti-psychotic be less effective if co-administered with Cogentin? Question 2 Using two diagrams, one at initiation of treatment and one after6 weeks of treatment, expla in the mechanism of action SSRIS and the hypothesis for delayed therapeutic effect. What would happen if a...
The enzymes involved in dTTP synthesis have been a target for many anti-cancer and immunosuppressant drugs....
The enzymes involved in dTTP synthesis have been a target for many anti-cancer and immunosuppressant drugs. Why?
3. Many chemotherapy drugs used to treat cancer work by modifying the mitotic spindle. Given the...
3. Many chemotherapy drugs used to treat cancer work by modifying the mitotic spindle. Given the short description of the two drugs here, describe how these drugs are effective in stopping cancer cells and where in the cell cycle they are effective. Paclitaxel works by interfering with normal microtubule breakdown during cell division and Vinblastine works by binding tubulin, thereby inhibiting the assembly of microtubules. 4. A researcher has developed three different cell lines that are able to each ignore...
. Find one example of an anti-cancer or anti- viral drug (other types of drugs are...
.
Find one example of an anti-cancer or anti- viral drug (other types of drugs are also okay) that has at least one chiral center in its structure. Write a brief overview of how this drug used and why it is effective (cite source!). Draw its structure and mark all the stereocenters with a star. Assign each stereocenter as R or S (in case the drug is used as a racemic mixture you can show one of the stereoisomers as...
You want to create an anti-cancer drug that destabilizes microtubules, hoping to prevent cell division in...
You want to create an anti-cancer drug that destabilizes microtubules, hoping to prevent cell division in the cancer cell line that you are studying. Which of the following drugs would enhance microtubule shrinkage and, therefore, utilize this mechanism of action? Answers A-D A a drug that inhibits GTP hydrolysis by the B-subunit in the GTP cap O B a drug that increases the ability of a tubulin dimer to bind to y-tubulin of the centrosome с a drug that increases...
please answer all parts 3. You are a physician prescribing a patient drugs to fight cancer....
please answer all parts
3. You are a physician prescribing a patient drugs to fight cancer. Describe the mechanism of action (how the drug works) of the drugs below and what type of cancer they are used to treat. a. Evista (Raloxifene Hydrochloride) b. Dactinomycin c. Cyramza (Ramucirumab) d. Abitrexate (Methotrexate)
13. Complete the following table (10-20 words each). Drugs Indication Mechanism of action Ibuprofen (Brufen) Pain
13. Complete the following table (10-20 words each). Drugs Indication Mechanism of action Ibuprofen (Brufen) Pain
Uses of SSRI's including withdrawal and monitoring of effect Anti-lipidemics mechanism of action and uses (Chapter...
Uses of SSRI's including withdrawal and monitoring of effect Anti-lipidemics mechanism of action and uses (Chapter 16) Cardiac glycosides uses and monitoring Drug interactions with diuretics (loop and distal tubular) and their uses ACEi clinical uses and mechanism of action (especially in angina, post MI and heart failure
What is the mechanism of action of commonly used lipid-lowering drugs, such as statins and ezetimibe?...
What is the mechanism of action of commonly used lipid-lowering drugs, such as statins and ezetimibe? What are SREBP and SCAP? What role do they play in the regulation of cholesterol homeostasis? What are the therapeutic options for the treatment of both heterozygous and homozygous forms of FH?
Question 1 Anti-cholinergic drugs (e.g. Cogentin) are effective in alleviating the symptoms of Parkinson's disease. Using a diagram, explain the mechanism of action of these drugs. Imagine a patient with Parkinson's and schizophrenia. Why would a typical anti-psychotic be less effective if co-administered with Cogentin? Question 2 Using two diagrams, one at initiation of treatment and one after6 weeks of treatment, expla in the mechanism of action SSRIS and the hypothesis for delayed therapeutic effect. What would happen if a...
3. Many chemotherapy drugs used to treat cancer work by modifying the mitotic spindle. Given the short description of the two drugs here, describe how these drugs are effective in stopping cancer cells and where in the cell cycle they are effective. Paclitaxel works by interfering with normal microtubule breakdown during cell division and Vinblastine works by binding tubulin, thereby inhibiting the assembly of microtubules. 4. A researcher has developed three different cell lines that are able to each ignore...
.
Find one example of an anti-cancer or anti- viral drug (other types of drugs are also okay) that has at least one chiral center in its structure. Write a brief overview of how this drug used and why it is effective (cite source!). Draw its structure and mark all the stereocenters with a star. Assign each stereocenter as R or S (in case the drug is used as a racemic mixture you can show one of the stereoisomers as...
You want to create an anti-cancer drug that destabilizes microtubules, hoping to prevent cell division in the cancer cell line that you are studying. Which of the following drugs would enhance microtubule shrinkage and, therefore, utilize this mechanism of action? Answers A-D A a drug that inhibits GTP hydrolysis by the B-subunit in the GTP cap O B a drug that increases the ability of a tubulin dimer to bind to y-tubulin of the centrosome с a drug that increases...
please answer all parts
3. You are a physician prescribing a patient drugs to fight cancer. Describe the mechanism of action (how the drug works) of the drugs below and what type of cancer they are used to treat. a. Evista (Raloxifene Hydrochloride) b. Dactinomycin c. Cyramza (Ramucirumab) d. Abitrexate (Methotrexate)
Uses of SSRI's including withdrawal and monitoring of effect Anti-lipidemics mechanism of action and uses (Chapter 16) Cardiac glycosides uses and monitoring Drug interactions with diuretics (loop and distal tubular) and their uses ACEi clinical uses and mechanism of action (especially in angina, post MI and heart failure
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