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Directions: Carefully read and respond to each question. Please complete your responses using complete sentences. Your...

Directions:

Carefully read and respond to each question. Please complete your responses using complete sentences. Your responses will be evaluated on the basis of content accuracy, clarity, correct usage of the English language, and demonstrated evidence of critical analysis.  

7.    In light of past breakthroughs for cancer treatment, do you think molecular medicine represents a significant breakthrough in the treatment for cancer or is it just another stop on a long road? Explain why or why not.

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Nowadays , cancer has become major health problem worldwide.

New , approaches for it are being continuously focussed . New, approach for cancer treatment involves specific targets of the cancer diseases.

Resistance to anticancer drugs is a well known clinical phoenomenon is now producing its secret to investigation at the molecular level, resistance to immunotherapeutic agent is a matter of concern that is influencing the effectiveness of anti cancer therapies, the acquired or instrinsic drug resistance directly impacts on survival and the prognosis of patients with cancer .

This type of reviews is representing the application of molecular targeted therapy in cancer treatments.

Due to increasing understanding of tumor immnoloimm leads to the development of effective targeted therapies.

Molecular diagnostic of cancer is also rapidly developed recently

, More and more targeted therapeutic agents across various cancer subtypes have been approved by US food and drug administration (FDA) in the past 10 years than in previous 2 decades, these treatments are safe and effective provide new treatment opportunity to the patient who could not receive suitable conventional therapy.

Oncoproteins that have gained tumor driving functions through mutations and overexpression are subsequently developed to increase specificity and to reduce the side effects, but there is also have such limitations.

Researchers have developed anticancer drug with a high molecular targeting precision, the cells are targeted and genetically altered in cancer cells and are essential to tumor development and survival.

Oncogene and oncoproteins are targeted and they are mainly involved in various signalling pathways are product of gene fusions, obtained and functional mutations or over expression of oncogenes .

1. Gene

HER2

MOLECULAR TARGET. Breast cancer

2. Gene

EGFR

MOLECULAR TARGET. Non small cell lung cancer

3. Gene

FLT3 -ITD

MOLECULAR TARGET. Acute myeloid leukaemia

4. Gene

VEGF & mTOR

MOLECULAR TARGET

Renal cell carcinoma

etc

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