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10. Use drug-response curve to answer the following questions: If A, B, and represent different drugs,...
Drugs A, B, and C are Dopamine Receptor Agonists used to treat Parkinson’s disease. Drug A has...
Drugs A, B, and C are Dopamine Receptor Agonists used to treat Parkinson’s disease. Drug A has an EC50of 30 mg/mL, Drug B has an EC50of 20 µg/mL, and Drug C has an EC50of 40 g/mL. Drug C is 50% less efficacious than Drugs A or B. Graph these drugs on a semi-log graded dose-response curve (all on one graph and label the axis). Can you determine the Kdof each of these drugs from the data (tell me why or why not too: HINT-look...
Which of the following is NOT provided by a graded dose-response curve? Select one: a. efficacy...
Which of the following is NOT provided by a graded dose-response curve? Select one: a. efficacy b. the level of physiological response to different drug concentrations Oc. median effective dose in a population to achieve a given response d. the dosage of a drug needed to obtain its maximal physiologic effect e. potency
The optimum use of chemotherapy drugs in combination is based on which premise(s)? Select all that...
The optimum use of chemotherapy drugs in combination is based on which premise(s)? Select all that apply. a. Drugs should have different mechanisms of action. b. Each medication should be effective by itself. c. Toxicity should concentrate in one body tissue. d. Overlappping toxicity among the agents should be minimal. e. Each drug should have the same mechanism of action. Response Rationale
Use the following information to answer questions 5 through 6. Investigators conducted a study among 400...
Use the following information to answer questions 5 through 6. Investigators conducted a study among 400 adults to determine the validity of a short form of the self-efficacy scale (SF) compared to the already established long form of the self-efficacy scale (LF). The LF contains 10 questions such as "There isn't much use in asking for a raise, since I probably won't get one anyway" to which persons answer with a number from 1 to 5, with 1 being "never...
47. A drug counselor thinks that young adults who use drugs are more likely to gamble...
47. A drug counselor thinks that young adults who use drugs are more likely to gamble than young adults who do not use drugs. To test this hypothesis, the drug counselor assessed the gambling habits of 180 young adults (25 years old). One group regularly drank alcohol, one group regularly smoked cigarettes, one group regularly used illegal drugs and one group did not use any drugs at all. The table are the results of a gambling questionnaire where higher scores...
The Newman Projections below all represent 2.3.3-trimethylhexane. Use them to answer the following four questions. Η...
The Newman Projections below all represent 2.3.3-trimethylhexane. Use them to answer the following four questions. Η H2 V VI VII VIII 20. Which Newman Projection represents the most stable conformation of 2,3,3-trimethylhexane looking down the 3-4 C-C bond? a. b. c. VIII I VII d. e. III IV 21. Of the options below, which represents the "gauche" conformation of 2,3,3-trimethylhexane down the 2-3 C-C bond? a. II c. VỊ b. V d. I 22. Which answer choice correctly orders the...
The Newman Projections below all represent 2,3,3-trimethylhexane. Use them to answer the following four questions H...
The Newman Projections below all represent 2,3,3-trimethylhexane. Use them to answer the following four questions HTH H HT H VI VII VIII 20. Which Newman Projection represents the most stable conformation of 23,3-trimethylhexane looking down the 3-4 C-C bond? a VIII d. III b. I e. IV c. VII 21. Of the options below, which represents the “gauche” conformation of 2,3,3-trimethylhexane down the 2-3 C-C bond? a. II 6. b. V d. I 22. Which answer choice correctly orders the...
Multiple Choice conned ov bluoWnois Use your critical-thinking skills to answer the following questions. Select the...
Multiple Choice conned ov bluoWnois Use your critical-thinking skills to answer the following questions. Select the correct answer. 1. The drug administration route demonstrating the slowest onset of action is (LO 2.1) A. inhalation B. transdermal C. intramuscular D. sublingual E. intravenous 2. In order for drugs to cross the blood-brain barrier, they must be (LO 2.2) A. ionized B. positively charged C. water soluble D. lipid soluble E. negatively charged 3. First-pass metabolism refers to the metabolism of drugs...
Matlab assigment
Assignment 2 ü You are encouraged to work in groups (maximum 3) on homework. ü For each part below, please provide the MATLAB code you implemented. ü Do not submit the homework solutions from previous years (The data are different). Dose-Response Modeling (100 points)Suppose that you work for a pharmaceutical company and you are supposed to assess the efficacy and potency of two drugs (Agent A and Agent B) before allowing the agents to proceed to clinical trials. You performed a...
K #11 4. Peaks #8, #9, and #10 in this chromatogram represent polarmolecules. Pea is known to be ...
k #11 4. Peaks #8, #9, and #10 in this chromatogram represent polarmolecules. Pea is known to be caused by a nonpolar compound, but does have a large molecular weight. Suppose the analysis is shown on a nonpolar stationary phase. It was lat repeated on a much more polar column. What effect could this most likely have on peak # 1 17(appear in front oftheotherthreeiappearfurther totheright ofthe other threei no effect) Be sure to rationalize your choice for full credit....
Which of the following is NOT provided by a graded dose-response curve? Select one: a. efficacy b. the level of physiological response to different drug concentrations Oc. median effective dose in a population to achieve a given response d. the dosage of a drug needed to obtain its maximal physiologic effect e. potency
Use the following information to answer questions 5 through 6. Investigators conducted a study among 400 adults to determine the validity of a short form of the self-efficacy scale (SF) compared to the already established long form of the self-efficacy scale (LF). The LF contains 10 questions such as "There isn't much use in asking for a raise, since I probably won't get one anyway" to which persons answer with a number from 1 to 5, with 1 being "never...
47. A drug counselor thinks that young adults who use drugs are more likely to gamble than young adults who do not use drugs. To test this hypothesis, the drug counselor assessed the gambling habits of 180 young adults (25 years old). One group regularly drank alcohol, one group regularly smoked cigarettes, one group regularly used illegal drugs and one group did not use any drugs at all. The table are the results of a gambling questionnaire where higher scores...
The Newman Projections below all represent 2.3.3-trimethylhexane. Use them to answer the following four questions. Η H2 V VI VII VIII 20. Which Newman Projection represents the most stable conformation of 2,3,3-trimethylhexane looking down the 3-4 C-C bond? a. b. c. VIII I VII d. e. III IV 21. Of the options below, which represents the "gauche" conformation of 2,3,3-trimethylhexane down the 2-3 C-C bond? a. II c. VỊ b. V d. I 22. Which answer choice correctly orders the...
The Newman Projections below all represent 2,3,3-trimethylhexane. Use them to answer the following four questions HTH H HT H VI VII VIII 20. Which Newman Projection represents the most stable conformation of 23,3-trimethylhexane looking down the 3-4 C-C bond? a VIII d. III b. I e. IV c. VII 21. Of the options below, which represents the “gauche” conformation of 2,3,3-trimethylhexane down the 2-3 C-C bond? a. II 6. b. V d. I 22. Which answer choice correctly orders the...
Multiple Choice conned ov bluoWnois Use your critical-thinking skills to answer the following questions. Select the correct answer. 1. The drug administration route demonstrating the slowest onset of action is (LO 2.1) A. inhalation B. transdermal C. intramuscular D. sublingual E. intravenous 2. In order for drugs to cross the blood-brain barrier, they must be (LO 2.2) A. ionized B. positively charged C. water soluble D. lipid soluble E. negatively charged 3. First-pass metabolism refers to the metabolism of drugs...
k #11 4. Peaks #8, #9, and #10 in this chromatogram represent polarmolecules. Pea is known to be caused by a nonpolar compound, but does have a large molecular weight. Suppose the analysis is shown on a nonpolar stationary phase. It was lat repeated on a much more polar column. What effect could this most likely have on peak # 1 17(appear in front oftheotherthreeiappearfurther totheright ofthe other threei no effect) Be sure to rationalize your choice for full credit....
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