Please help me on my Medicinal Chemistry paper
Please answer my question with more explanations and based on the medicinal chemistry concept. Also. Please type the answer with detailed explanations. Thanks please no plagiarisms.
The topic of my paper is “Medicinal Chemistry Approaches for the Treatment and Prevention of Alzheimer’s disease”
Cholinomimetic Agents for Alzheimer's disease treatment are
galantamine and donepezil, it increases the action of dependent
dopamine release. these both are acetylcholinesterase inhibitors.
these components improve the learning, memory of attention ability.
these drugs alter the catecholamine release and act in cognitive
symptoms of dementia.
cholinergic hypothesis dysfunction of acetylcholine contains
neurons in the brain it influences an increase cholinergic
hypothesis of AD to make biochemical and histopathological changes
of neurotransmitter markers in brains. Deficient in excitatory
amino acids (EAA)neurotransmission have an important role in the
cholinergic system in the modulator of EAA neurotransmission. these
components delay the symptoms of AD and make the progressive nature
of the disease.
AChE inhibitors improve cognitive, behavior and ADL and AD
functions. It improves the underlying cholinergic system deficit in
AD, drugs to treat AD are galantamine, rivastigmine, and
donepezil.
Galantamine prevents the breakdown of acetylcholine, it treats mild
to moderate Alzheimers and dementia. The recommended dose of this
drug is 4mg PO q12 h.
Rivastigmine is cholinesterase inhibitor to treat mild to moderate
AD and Parkinson's, recommended dose is 1.5mg POq12h
Donepezil treats mild to moderate Alzheimer's disease, it inhibits
the AChE, the enzyme degrades the acetylcholine after release from
presynapse and increases the availability of acetylcholine in
cholinergic synapse. the recommended dose is 5-10mg PO HIS
Please help me on my Medicinal Chemistry paper Please answer my question with more explanations and...
Please help me on my Medicinal Chemistry paper Please answer my question with more explanations and based on medicinal chemistry concept. Also. Please type the answer. Thanks The topic of my paper is “Medicinal Chemistry Approaches for the Treatment and Prevention of Alzheimer’s disease” Is it age related diseases? If yes who is more affecting? And why? Which part of the world (continent) more common and affecting by this disease? Is hygiene care make a difference if yes how? How...
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