Question

A mother who is O Rh negative gives birth to a baby who is A Rh positive. The baby has been diagnosed as having ABO HDFN and may need a transfusion. Please answer the following questions regarding this case. Each correct answer is worth 11 points. Level of discussion is worth a maximum of 12 points. Explain the mechanism by which fetal sensitization occurs in hemolytic disease of the fetus and newborn. Which antibody is likely responsible for this ABO HDFN? Why is bilirubinemia not a concern when the baby is in utero? Why is it a concern after birth? What blood type and what characteristics should the RBCs prepared for transfusion have? A Kleihauer-Betke stain was performed on the mother’s blood and showed 4.5% fetal cells. How many vials of Rh immune globulin should be given to this woman? List two ways in which you can safeguard against CMV infection from transfused blood products. Why is ABO less severe than Rh HDFN? What test is critical for detecting HDFN? Why is it critical? If this test is positive, what needs to be done?

Answer 1

Rh negative factors of mother 's blood cause baby suffering from hemolytic newborn disease, mother' s rh antibody enter in newborn via igG antibody and cross placenta cause hemolytic reactions.

For prevention of this crisis require O negative blood, which react with this crisis or no more antigen antibody reactions. o prevent against rh incompablity

4 vials should be use, but not more than 5.

For prevention against cmv, transfused blood should be seronagative blood products.

Provision of Cmv-negative blood product.

ABO incompablity is less severe than RH incompablity because neonate red blood cells have few A, B, antigen on red blood cells compare to RH antigen.