Homework Answers
d.
For drugs with high extraction ratio, the organ is capable of removing sll the drug presented to it, independently of pladma binding. Therefore, even if the fraction of unbound drug, increases, the clearsnce remains constant and the unbound concentration then increases and may lead to toxicity.
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Drug A is a High extraction ratio drug and it is mostly eliminated by hepatic metabolism....
Hepatic Clearance Practice Problems PH4330 1. Normal CL value for this drug is 0.5 L/min and...
Hepatic Clearance Practice Problems PH4330 1. Normal CL value for this drug is 0.5 L/min and elimination is via the liver. V 100 L a. Is this a low, intermediate, or high E drug? b. In CHF (congestive heart failure) patient, Q is half the normal value of 800 ml/min. What would the hepatic clearance be in the CHF patient? What would be the normal and CHF FFp values? c. 2. Given the following pharmacokinetic information for a drug: .Q...
Typical pharmacokinetic parameters of DRUG-A are F-0.02; fex < 0.1; fu 0.3; V- 0.22 L/Kg Half-life...
Typical pharmacokinetic parameters of DRUG-A are F-0.02; fex < 0.1; fu 0.3; V- 0.22 L/Kg Half-life 4 hours. Drug-A is administered as a continuous IV-Infusion to a patient taking another medication that is known to induce the hepatic-metabolism of Drug-A. Therefore, the time to reach steady state will: D Increase 0 Decrease O Show little difference
I know a is .458mg/L; b is 1.977hr; c is 368mg; d is 17.35 L/hr. Co=...
I know a is .458mg/L; b is 1.977hr; c is 368mg; d is 17.35 L/hr.
Co= 7.36mg/L and ke=.347 1/hr. I need help with E and F. I'm not
sure how to calculate them.
Q1. A drug is eliminated through glomerular filtration and hepatic metabolism. It does not bind to plasma proteins. Glomerular filtration rate is normal. The drug does not undergo active renal secretion and passive or active reabsorption after renal filtration is observed. The volume of distribution is...
Provide an overview of the pharmacokinetics of neonates and infants. Discuss drug absorption in neonates and...
Provide an overview of the pharmacokinetics of neonates and infants. Discuss drug absorption in neonates and infants, focusing on a drug’s physicochemical properties and its effects on absorption. Discuss drug absorption as it relates to the route of administration in pediatric patients. Discuss factors directly related to drug distribution in neonates and infants (e.g., protein binding and the blood–brain barrier). Discuss hepatic metabolism and compare the drug-metabolizing capacity of a newborn with that of a 1-year-old infant. Discuss renal excretion...
For questions 41-43 consider the following scenarno: An overdose of a new system including vertigo, ataxia...
For questions 41-43 consider the following scenarno: An overdose of a new system including vertigo, ataxia began within 15 minutes after oral administration of the drug. No metabolic breakdowih were found in the urine (pH was 5.5). However, a high concentratio the bile. The following information was obtained from the manufacturer. The drug is an orgai acid with a pk, of 6.4 and high lipid solubility and the drug is excreted by humans so that or the administered dose is...
2. A client with high blood pressure of 188/104 mmHg takes a potent vasodilating drug to...
2. A client with high blood pressure of 188/104 mmHg takes a potent vasodilating drug to lower the blood pressure. One hour after administration, the BP has decreased to 135/78 in response to the drug. Which additional assessment finding is an expected response to this rapid change in BP? Provide a detailed rationale for the answer you selected. a. Capillary refill of 2 seconds b. Rubor when legs dangling c. Pulse increase of 20-30 beats/min d. Urine output increase of...
PN 200 Fundamentals of Nursing II Urinary System/Antihypertensive Med Take Home Pharmacology Test Multiple Choice Identify...
PN 200 Fundamentals of Nursing II Urinary System/Antihypertensive Med Take Home Pharmacology Test Multiple Choice Identify the choice that best completes the statement or a wer the question 1. When assessing a 40-year-old patient, the nurse observes an increase in the client's blood pressure. Which of the following changes in blood pressure is indicative of prehypertension? a Systolic pressure between 120 and 139 mmHg b. Systolic pressure between 100 and 119 mmHg c. Systolic pressure between 80 and 99 mmHg...
Question 1- Please choose the correct answer inside the bracket and copy it to your answer...
Question 1- Please choose the correct answer inside the bracket and copy it to your answer sheets (12 Marks) a. Given a bank's return on assets, the higher the bank capital, the (higher/lower) the return for the owners of the bank b. Greater flexibility in liability management has allowed banks to (increase/decrease) the proportion of their assets held in loans. C. In the absence of regulation, banks would probably hold too little capital, (increasing/ decreasing) the return on equity. d....
Review Constants Periodic Table Air consists mostly of nitrogen (N), with a molecular mass of 28, and oxygen (O2),...
Review Constants Periodic Table Air consists mostly of nitrogen (N), with a molecular mass of 28, and oxygen (O2), with a molecular mass of 32. A water molecule (H,O) has molecular mass 18. According to the ideal gas law (N/ V P /KT), dry air at a particular pressure and temperature has the same particle density (number of particles per unit volume) as humidait at the same pressure and temperature. Consequently, humidair, whose low-mass water molecules replace more massive nitrogen...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
Hepatic Clearance Practice Problems PH4330 1. Normal CL value for this drug is 0.5 L/min and elimination is via the liver. V 100 L a. Is this a low, intermediate, or high E drug? b. In CHF (congestive heart failure) patient, Q is half the normal value of 800 ml/min. What would the hepatic clearance be in the CHF patient? What would be the normal and CHF FFp values? c. 2. Given the following pharmacokinetic information for a drug: .Q...
Typical pharmacokinetic parameters of DRUG-A are F-0.02; fex < 0.1; fu 0.3; V- 0.22 L/Kg Half-life 4 hours. Drug-A is administered as a continuous IV-Infusion to a patient taking another medication that is known to induce the hepatic-metabolism of Drug-A. Therefore, the time to reach steady state will: D Increase 0 Decrease O Show little difference
I know a is .458mg/L; b is 1.977hr; c is 368mg; d is 17.35 L/hr.
Co= 7.36mg/L and ke=.347 1/hr. I need help with E and F. I'm not
sure how to calculate them.
Q1. A drug is eliminated through glomerular filtration and hepatic metabolism. It does not bind to plasma proteins. Glomerular filtration rate is normal. The drug does not undergo active renal secretion and passive or active reabsorption after renal filtration is observed. The volume of distribution is...
For questions 41-43 consider the following scenarno: An overdose of a new system including vertigo, ataxia began within 15 minutes after oral administration of the drug. No metabolic breakdowih were found in the urine (pH was 5.5). However, a high concentratio the bile. The following information was obtained from the manufacturer. The drug is an orgai acid with a pk, of 6.4 and high lipid solubility and the drug is excreted by humans so that or the administered dose is...
2. A client with high blood pressure of 188/104 mmHg takes a potent vasodilating drug to lower the blood pressure. One hour after administration, the BP has decreased to 135/78 in response to the drug. Which additional assessment finding is an expected response to this rapid change in BP? Provide a detailed rationale for the answer you selected. a. Capillary refill of 2 seconds b. Rubor when legs dangling c. Pulse increase of 20-30 beats/min d. Urine output increase of...
PN 200 Fundamentals of Nursing II Urinary System/Antihypertensive Med Take Home Pharmacology Test Multiple Choice Identify the choice that best completes the statement or a wer the question 1. When assessing a 40-year-old patient, the nurse observes an increase in the client's blood pressure. Which of the following changes in blood pressure is indicative of prehypertension? a Systolic pressure between 120 and 139 mmHg b. Systolic pressure between 100 and 119 mmHg c. Systolic pressure between 80 and 99 mmHg...
Question 1- Please choose the correct answer inside the bracket and copy it to your answer sheets (12 Marks) a. Given a bank's return on assets, the higher the bank capital, the (higher/lower) the return for the owners of the bank b. Greater flexibility in liability management has allowed banks to (increase/decrease) the proportion of their assets held in loans. C. In the absence of regulation, banks would probably hold too little capital, (increasing/ decreasing) the return on equity. d....
Review Constants Periodic Table Air consists mostly of nitrogen (N), with a molecular mass of 28, and oxygen (O2), with a molecular mass of 32. A water molecule (H,O) has molecular mass 18. According to the ideal gas law (N/ V P /KT), dry air at a particular pressure and temperature has the same particle density (number of particles per unit volume) as humidait at the same pressure and temperature. Consequently, humidair, whose low-mass water molecules replace more massive nitrogen...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
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