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Explain why patients with prostatic hypertrophy often have urinary retention, and analyze the pathophysiologic mechanism(s) a
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In prostatic hypertrophy, the prostate glands get enlarged slowly with hypertrophy or hyperplasia of normal tissue.It leads to the inflammation of local tissues and compression of the urethra resulting in partial or complete obstruction of urine.

*Pathophysiology

Prostate hyperplasia

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Urethral resistance increases

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Changes in bladder function

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Changes in detrusor function

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BPH related problems (Nocturia, Urinary retention, urinary Urgency)

*Drug of choice

Doxazosin (alpha1 blockers)

It blocks the alpha1 receptors in the arteries ,CNS and smooth muscles as well as reduce the resistance of the arteries.

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