Question

7.30 The enzyme chitinase is selectively inhibited by the natural product inhibitor allosamidin. On the basis of the analogy between allosamidin and a key mechanistic intermediate, suggest a plausible arrow-pushing mechanism for chitinase. allosamidin HONHACHO GAS HO HO NE NHAC HO HNMe2

Answer 1

sol:- Allosamüdin is a chalinas. Ophibitor Produced from strepto my ces species. chilin is the subslance found in the cell wall of plants and organisms like fungus. chitinase is the enzyme found in organims . that either want to reshape their structure of to dissolve the chitin present in animals and lingus. at ad by hydrolyzing the ß 1,4 linkage of N-acetyl glucosamine. - Allosamidin did not promote the production of Chitinase enzyme. But in Presence of N,N-diacetylchitokiose adhich also enhances the production of same chitinase enzeme. These show that allosamidin Can regulate Chitinase enzyme production by two Component regulatory system in presence N,N-diacety (chitobiose CH3 OH Homo Paco -3 HO chaton C - Cth Homo I odazotum intermedeate. He allosami soline allosamidin. COUNT