Question

Question 1 Not yet answered Carl trips during baseball practice and scrapes his knee. About a week later, the area develops a bacterial infection which migrates to the deeper tissue. Carl is hospitalized so that he can receive i.v. antibiotics. He prefers to take the antibiotics orally, but the hospital pharmacist tells Carl that this is not possible because: Points out of 1.0 Select one: Flag question a. The drug doesn't taste good b. The drug is lipophilic and is completely absorbed by the intestine C. The drug is eliminated by first-order kinetics d. The drug has a low first-pass effect e. The drug has a low oral bioavailability

Answer 1

E. The drug has low oral bioavailability

• Bioavailability is the fraction of administered drug that reaches systemic circulation in unchanged form. By IV route, bioavailability is 100% because it bypass first pass metabolism by liver. Therefore the drugs having low oral bioavailability are given by IV or some other route
• Generally the bioavailability of oral drug is low. This is because they have high first pass metabolism in liver.

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