Which is more reactive toward nucleophilic attack, an aldehyde or a ketone? There are at least...
1. Explain why aldehyde A is more reactive to nucleophilic addition reactions than ketone B.
1. Explain why aldehyde A is more reactive to nucleophilic addition reactions than ketone B.
When an aldehyde or ketone undergo a nucleophilic attack, the reaction follows a nucleophilic addition mechanism. Conversely, carboxylic acids and their derivatives are known to undergo nucleophilic acyl substitution. Even though all of these functional groups are defined by the carbonyl group, they react very differently. In 1-3 sentences, explain why an aldehyde and a carboxylic acid derivative follow different mechanistic pathways in the presence of a nucleophilic species.
Condensation Reactions Homework (Chapter 19) NAME 1. Explain why aldehyde A is more reactive to nucleophilic addition reactions than ketone B. В 2. Give the curved arrow mechanism for each aldol reaction. O Он NaOH a. Н.о Н Н ОН NaOH Н.о NaOH, H2O heat Н NaOH, H2O d. heat н"
Condensation Reactions Homework (Chapter 19) NAME 1. Explain why aldehyde A is more reactive to nucleophilic addition reactions than ketone B. 2. Give the curved arrow mechanism for each aldol reaction. est NaOH, H, heat NaOH, H, heat 3. Give the major organic aldol product for each reaction, along with the dehydration produs possible) formed after heating. NaOH H,0 heat NaOH heat HO heat NaOH HO
Which carbonyl is more susceptible to nucleophilic attack, cyclohexanone or hexanal? Provide two reasons for this choice and explain each one.
Rank the following carbonyl-containing compounds in order of reactivity towards nucleophilic attack. Most Reactive to least reactive. 3-methylpentanoyl chloride, acetic anhydride, hexyl propanoate, N,N-diphenylethanamide, butanedial, and propanone.
Please rank the following acid derivatives from most reactive to least reactive toward nucleophilic attacks and explain your reasoning. 1. NH2 2. Please show how you would accomplish the following synthesis. heptanoyl chloride heptanoic anhydride CI cyclopentanecarbonyl chloride 2-propyl cyclopentanecarboxylate heptanoyl chloride N-cyclohexylheptanamide OH cyclopentyl acetate cyclopentanol
List the following carbonyl compounds in order of decreasingreactivity toward nucleophilic addition: ester, acid chloride,amide, aldehyde, ketone.
Which acid derivative is the most reactive with respect to nucleophilic attack? CI O B O C O D