Question

Azides are often used in [3+2] cycloadditions to form fluorescent markers used in biochemistry. What are some safety concerns of azides? Intramolecular Diels-Alder reactions have become increasingly important in synthesis. Draw carefully the structure of the product expected from heating the following compound. What is the minimum value of (n) necessary to allow the intramolecular reaction to proceed? (Models are useful here). CO Et

Answer 1

3. safety concerns of Azide Azides are molecules with wide ranging of applications. R-N=N=N However, One should be extremely cautions while using time them. • They are shock-sensitive They can explosively decompose with evolution of Ne gas with little external source of heating Exposure to NaNz can callse. rapid breathing, nausea, restlessness, dizziness, headache, skin burns et. • One should not use halogenated solvents (eg: CH₂C2) for NaNz reactions because it can form explosive Sheltz 1. One should not concentrate azide- I Containing reaction mixture through I rotasy evaporation or distillation 1. One should not use metal shatualas I for weighing & transferring azides.