5. (25 Points) Draw all products for the following two reactions. Be sure to indicate stereochemistry...
6) Predict the major product in each of the following reactions and indicate if it came from an Sn1, S2, E1, or E2 reaction. H3C Br NaOme CH3 H2O H Br MeOH 'BUOK H Br DMSO H3C Br NaOme CH3 H20 MeOH H OTS ЕКОН
Question 2. (20 marks) In the reactions below, draw the MAJOR product in the box provided and indicate in the small box whether the reaction is Sn1, S2, E1 or E2. Be sure to show all necessary stereochemistry. If more than one enantiomer is produced, write "+En" in the box with the product. Product Sy1/S2/E1/E2 H2SO4 Heat OH HC (44) OH NaOH NaCN DMSO, Cold NaOtBu Page 3 of 11
4. Predict the products of the following reactions & indicate whether they are most likely to go through an SN2, SN1, E1, or E2 mechanism. NaCN DMSO NaOH CH3OH heat Only one product is formed in the following E2 elimination reaction. Draw an arrow-pushing mechanism for the reaction and provide the correct product structure. Include a 3-D drawing (chair conformation) displaying proper stereochemistry of the transition state to explain formation of only the major product. CH3 •Br NaOCH3 ~"'CHS
draw the structures of the major organic products of each of the following reactions. be sure to indicate stereochemistry when it is relevant. CH3CH2 Н. CH2CH3 НЭРОД HI (E1) С. CH3 CI Н Na OCH2CH3 CH3CH2 Но CНЗ ECH2CH3 (E2) CH3 CI d.
Draw the structural formula for the reagents and the products for the following reactions. Watch the stereochemistry where appropriate. Indicate the mechanism for each (E1, E2, SN1, SN2). The reaction of t-butylbromide with a strong base and heat. The reaction of R-2-bromobutane with methanol. The reaction of R-2-bromobutane with sodium methoxide in acetone. The reaction of R-2-bromobutane with sodium t-butoxide and heat. The reaction of 2-methyl-2-iodopentane with water.
3. For each of the reactions shown below, predict the single major product and determine which mechanism, S1, Sh2, E1, or E2, is operative. Briefly justify your choice. Be sure to indicate stereochemistry in the product if it is relevant s Ko'Bu BUOH C. conc. H2SO4 d. [1 equiv ) NaOMe Br MeOH
In the substitution reactions below, draw the major product in the box provided and indicate in the small box whether the reaction is SN1, SN2, or neither. Be sure to show all stereochemistry. If more than one enantiomer is produced, write "+Enant" in the box with the product. [10] Product SN1/SN2/Neither NaCN Br DMSO NaOEt EtOH Br NaOMe MeOH NaOH Expensive Acetonitrile CH,Br DMF Nat
raw the organic products produced in each of the following reactions. For partial credit, indicate whether the reaction is an E1, E2, S1. or S2 reaction on the line provided. Show stereochemistry when relevant. (19 pts) H₂ CH₂ нстве CH,OH HS acetone CH, Br e 99 cach. 9 CEC-H DMF e KUN DMSO Осн. CH, OH, 50°C
For the following dehydrohalogenation (E2) reactions, draw all Zaitsev products, showing the stereochemistry clearly. Show the product stereochemistry clearly. If there is more than one organic product, both products may be drawn in the same box.
2. (1.5 pts) Label the following reagents as Good or Poor Nucleophiles AND as Strong or Weak Bases. OK Na SH 3. (1.5 pt) Predict the productts) of the following reactions, if there are multiple products indicate which, if any, is the major product. Be sure to clearly mark the stereochemistry of chiral carbon atoms and draw multiple products if there is more than one stereoisomer that forms. HCI MeOH H2SO H2 Pd/BaSO4 quinoline 4. (3 pt) For the following...