Question

8. Ranolazine for angina patients 9. Recommendations for HF - stages A-D 10. Cholesterol lowering drugs and considerations for prescribing 11. Statin use in children, pregnancy, and contraindications for use 12. Diuretics-types of and differences between diuretics

Answer 1

Ranolazine is a relatively new drug, with a unique mechanism of action, used for the treatment of angina. Ranexa has been shown to significantly improve the number of time patients with stable angina are able to exercise before developing symptoms and was approved by the FDA in 2008 as a first-line agent for angina.

INDICATIONS

indicated for the treatment of chronic angina.RANOLAZINE may be used with beta-blockers, nitrates, calcium channel blockers, anti-platelet therapy, lipid-lowering therapy, ACE inhibitors, and angiotensin receptor blockers.

DOSAGE AND ADMINISTRATION

Dosing Information

Initiate RANOLAZINE dosing at 500 mg twice daily and increase to 1000 mg twice daily, as needed, based on clinical symptoms. Take RANOLAZINE with or without meals.

The maximum recommended daily dose of RANOLAZINE is 1000 mg twice daily.

Dosage Forms And Strengths

RANPLAZINE is supplied as film-coated, oblong-shaped, extended-release tablets in the following strengths:

• 500 mg tablets are light orange, with GSI500 on one side
• 1000 mg tablets are pale yellow, with GSI1000 on one side

Storage And Handling

RANEXA is supplied as film-coated, oblong-shaped, extended-release tablets in the following strengths:

• 500 mg tablets are light orange, with GSI500 on one side
• 1000 mg tablets are pale yellow, with GSI1000 on one side

Ranolazine extended-release tablets are available in:

	Strength
Unit-of-Use Bottle (60 Tablets)	500 mg
Unit-of-Use Bottle (60 Tablets)	1000 mg

In addition, people with cirrhosis (scarring) of the liver should not take RANOLAZINEand neither should people taking St. John's wort and certain other medications for:

• fungus infections
• infections
• depression
• HIV
• tuberculosis (TB)
• seizure.