Question

6. MAO's 7.SSRIS SNRIS, TCAS 8. Ranolazine for angina patients 9. Recommendations for HF-stages A-D 10. Cholesterol lowering drugs and considerations for prescribing 11. Statin use in children, pregnancy, and contraindications for use 12. Diuretics -types of and differences between diuretics 13. Antihypertensives-types, when to start, adherence issues 14. decongestants and antihistamines-types, contraindications, side effects 15. Treatment of asthma - during pregnancy, stepwise approach, monitoring 16. Tobacco cessation - correct usage of Chantix and other drugs useful for smoking cessation, patient education, contraindications 17. TB treatment regimen 18. Warfarin, clopidogrel, ASA, Coumadin uses and patient education

Answer 1

6).

Monoamine oxidase (MAO) enzymes are involved in the metabolism of catecholamines. They oxidize the amines and remove the amine group. The two types of MAO are MAO-A, and MAO B. Both the MAO A and MAO B are found in the central nervous system. Outside the CNS, the MAO-A is present in the GIT, vascular endothelium of the lungs, liver, and placenta. MAO B enzyme is present in the platelets.

The primary substrates of MAO-A are serotonin, adrenaline, noradrenaline, and melatonin. The substrates of MAO B are benzylamine and phenethylamine.

Monoamine oxidase inhibitors (e.g.: selegiline, phenelzine) or MAOIs inhibit the metabolism of monoamines (adrenaline, noradrenaline, dopamine, and serotonin) by the “monoamine oxidase” enzyme. This increases their availability at the nerve terminals and thus, increase the transmission. MAOIs are generally prescribed in the treatment of depression and Parkinson’s disease.