Question

how hypoxia and cyatic fibrosis relate?

Ho poxia and oystic foruss Reflection

Answer 1

Q. How hypoxia & cystic fibrosis relates? dns: Hypoxia is 02 deficiency at the tissue level. It is a pathological condition in which the whole body as a whole or a region of the body is deprived of adequate oxygen supply. -> Cystic fibrosis is an autosomal recessive genetic disorder that affects epithelial cells of the respiratory, gastrointestinal y reproductive tracts & leads to åbnormal exocrine gland secretion → In cystic fibrosis there is an alteration in the viscosity & tenacity of muens produced at epithelial Surfaces. → cystic fibrosis is often associated with low Hb oxygen saturation and with limited exercise tolerance → In cystic fibrosis CFTR gene is mutated & doesn't work. - cf is due to a mutation in the CF gene on chromosome 7°CF gene encodes a protein known as the cystic fibrosis trans membrane regulator. (CFTR) - The cibnormal CFTR protein in patient with CF leads to disruption of chloride channels on the cello - Detective chloride transport cause more water & sodium reaksprption than normal.

-secretion in affected organs becomes thick & viscous 2 obstructing glands & ducts Dilatation of the secretory glands causes damage to the exocrine tissue - Blood flowing to infected areas of the lung is not re-soute by the CFTR protein resulting in impaired blood oxygénation causing hypoxia.