8. Give the product of a Robinson annulation on the ketone below. Ноо
Write the structure of the Michael addition product and the
final Robinson annulation product when using the following starting
materials.* The dialdehyde is the Michael donor and the ketone is
the Michael acceptor. Will rate and comment, thanks!
*PLEASE IDENTIFY THE STRUCTURES OF MICHAEL ADDITION AND FINAL
ROBINSON ANNULATION PRODUCT
Н. Michael addition product Robinson annulation product
Write the structure of the Michael addition product and the final Robinson annulation product when using the following starting materials. Hint: the dialdehyde is the Michael donor and the ketone is the Michael acceptor. H ze Michael addition product Robinson annulation product
Draw the product that results from a Robinson Annulation
reaction.
. (4 points) Draw the product that results from a Robinson Annulation reaction. You are not required to show a mechanism. NaOH H2O/EVOH Robinson Annulation Product
1. A Robinson annulation is a reaction that involves: (i) a Michael addition of an enolate onto an ,ß-unsaturated enone followed by (ii) an intramolecular aldol reaction. The molecule shown below (cyclohexenone X) can be made through two different Robinson annulation reactions. (A) Show the two different sets of starting materials (i.e. ketone 1 &a,p-unsaturated enone 1 and ketone 2 & a,B-unsaturated enone 2) for each Robinson annulation. Draw the reagents/reaction conditions. (B) Then pick one set and draw an...
Propose a synthesis and predicted final product. Include
mechanisms
(a) Hint: vinyl Grignard, Robinson annulation CN (b) Hint: the synthesis can start with halogenation. It will go through an alkyne, which will be alkylated to form an intermediate Cotle. Ketone? Another hint: at some point, you may think of doing Robinson annulation 1.t-BuOK 2. Mel 1. LDA, THF -78 °C 2. benzaldehyde 3. Acid work-up O NaOH(aa) heat
28. Which intermediate is not on the mechanistic pathway directly leading to the Robinson annulation product?: ONa ONa & Gare A. ONa 29. The Robinson annulation is best described as a(n): A. aldol followed by a conjugate addition B. Michael reaction followed by an aldol C. double aldol followed by an E1cb elimination D. alkylation, then aldol, then a Michael addition 30. Select the product for the reaction shown below: НО. KOH o ? T A. B. C. D.
4. Provide reasonable product structures. If you provide a mechanism for the Robinson Annulation a 10 pt bonus will be awarded. CD NaOEt و سلم . و Robinson Annulation OEt + Cu /
Mechanism 5. The following reaction illustrates a Robinson annulation reaction. Give a complete stepwise mechanism for the reaction. [8 points OH
28. Which intermediate is not on the mechanistic pathway directly leading to the Robinson annulation product?: ONa ONa & Go & ONa A. ONA OH D 29. The Robinson annulation is best described as a[n): A. aldol followed by a conjugale addition B. Michael reaction followed by an aldol C. double aldol followed by an E1cb elimination D. alkylation, then aldol, then a Michael addition
The following reaction illustrates a Robinson annulation reaction. Give a complete stepwise mechanism for the reaction. The reaction.