Question

Match the oral antidiabetic class with its mechanism of action Sulfonylureas [Choose Decreased the production and increases the uptake of glucose in the liver Delay glucose absorption in the intestine Increases insulin secretion through a G protein receptor mediated response; decreases release of glucagon Inhibits action of DDP - 4 and increasing GLP-1 resulting in increased insu lin secretion, decreased glucagon secretion and Stimulate insulin release and have a short duration and half life compared to sulfonylureas Blocks glucose reabsorption in the kidney to lower blood glucose levels Decrease insulin resistance by enhancing insulin receptors Stimulate pancreatic beta cells to secrete more insulin Biguanide Metglitinides Thiazolidinediones Choose Alpha glucosidase inhibitors [Choose] Dipeptidyl -peptidase 4 inhibitors (DDP-4 Inhibitors) Choose GLP-1 Receptor Agonists Incretin Mimetics [Choose SGLT2 Inhibitors = Sodium-glucose co- [Choose transporter 2

Answer 1

Sulfonylureas: stimulate pancreatic beta cells to secrete more insulin

Biguanides: decrease the production and increase the uptake of glucose in the liver

Metglinides: stimulate insulin release and have short duration and half life compared to sulphonylureas

Thiazolidinediones: decrease insulin resistance by enhancing insulin receptors

Alpha-glucosidase inhibitors: delay glucose absorption in intestine

DDP-4 inhibitors: are used to inhibit the action of DDP-4 and increasing GLP-1 resulting in increased insulin secretion and decreased glucagon secretion

GLP-1 receptor agonists: increase insulin secretion through G protein mediator response and decrease the secretion of glucagon

SGLT-2 inhibitors: inhibit reabsorption of glucose in the kidney to lower blopod glucose level