For the following reaction, (a) predict the reaction pathway (SN2, E2, S1/E1) based on our predictive...
For the following reaction, (a) predict the reaction pathway (SN2, E2, S1/E1) based on our predictive model and (b) draw the product(s). ONa Provide the complete curved arrow mechanism for the rearrangement shown here. Hint: The first step makes the alcohol a better leaving group using a proton source. Complete the following sequence by filling in missing reagents or providing the product(s) of a reaction. Sequential steps, if necessary, should be numbered. OMs ОН minor product major product
For the following reaction, (a) predict the reaction pathway (SN2, E2, SN1/E1) based on our predictive model and (b) draw the product(s). Provide the complete curved arrow mechanism for the rearrangement shown here. Hint: The first step makes the alcohol a better leaving group using a proton source. oleme Oy Complete the following sequence by filling in missing reagents or providing the product(s) of a reaction. Sequential steps, if necessary, should be numbered. OMs major product minor product
For the following reaction, (a) predict the reaction pathway (SN2, E2, SN1/E1) based on our predictive model and (b) draw the product(s). ONa
Complete the following sequence by filling in missing reagents or providing the product(s) of a reaction. Sequential steps, if necessary, should be numbered. How Toot OH OMs major product minor product
5. For each reaction below, indicate the major reaction pathway (SN2, SN1, E2 or E1) and draw the major product. KCN acetone, 15 °C A. Br OTs acetic acid, 80 °C K O C. O BuOH, 0C K O D. OMs CHCN, 50°C
21. Propose a mechanism to explain this reaction (SN1, SN2, E1 or E2). What is the structure of the product? H 22. How can we get this product? CI CI ?
Compare and contrast SN1, SN2, E1 and E2 reactions. What are some obvious similarities and differences between each reaction pathway? What are the requirements for each reaction to work? Discuss why SN2 is in direct competition with E2 while SN1 is in direct competition with the E1 reaction pathway. What is the rate expression for each? Which reactions are concerted? Which reactions are step-wise? Which reactions are stereospecific and what is the stereospecificity of each that are? How do the...
3. Shown below are a series of reactions. Predict the major product for each of them. Remember, you will need to first decide whether the reaction occurs by an SN2, SN1, E2, or E1 before you can determine what the product will be. Label each as SN2, SN1, E2, or E1. Hint: First decide whether S2/E2 or S1/E1 is favored, and then decide whether the reaction pathway goes by a substitution or elimination reaction. SN2 / SN1 E2/E1 Na DMSO,rt...
(a) (b) (c) (d) Predict the product(s) for the following reactions. Indicate the pathway (E1, E2, Sn1, SN2) for the formation of each product. CHRONa Br CH, OH NaSCHZ THE -Br Tso NaCN H2O TsO CH,CH ONa CH,CH,OH
1) Compare and contrast SN1, SN2, E1, and E2 reactions! (similarities abd differences. Requirements for each to work.) 2) Why is SN2 is in direct competition with E2 while SN1 is direct competition with E1 reaction. 3) Rate expression of each 4) which reactions are concerted? Which are atep wise? 5) which are sterospecific and what stereospecificity of each are? 6) how do the variables below (A-D) influence reaction pathway? Compare and contrast SNI, SN2, El and E2 reactions. What...